Date Available
11-24-2020
Year of Publication
2020
Degree Name
Master of Science (MS)
Document Type
Master's Thesis
College
Medicine
Department/School/Program
Medical Sciences
First Advisor
Dr. Mark Prendergast
Abstract
Ethanol consumption during pregnancy is rising in the U.S., including the rate of binge drinking. It is reported around 1 in 27 women engage in binge drinking activities while pregnant. The third trimester is a sensitive period of neuronal growth in which ethanol induced neurotoxicity can cause many harmful effects including Fetal Alcohol Spectrum Disorders. It has been shown that ethanol decreases the activity of AMPK through increasing lipid peroxidation, both of which are correlated to neurotoxicity. AICAR is a synthetic analog of AMP which significantly increases AMPK activity and may have beneficial effects in an organotypic hippocampal model of third trimester binge drinking. The purpose of this study is to evaluate if pharmacologically increasing the activity of AMPK could reduce the degree of ethanol induced neurotoxicity to provide a potential therapeutic target for Fetal Alcohol Spectrum Disorders.
Digital Object Identifier (DOI)
https://doi.org/10.13023/etd.2020.473
Recommended Citation
Gebhardt, Jessica, "ETHANOL INDUCED NEUROTOXICITY THROUGH DYSREGULATION OF AMPK IN A FETAL ALCOHOL SYNDROME MODEL" (2020). Theses and Dissertations--Medical Sciences. 14.
https://uknowledge.uky.edu/medsci_etds/14
