Date Available
4-22-2021
Year of Publication
2021
Degree Name
Master of Science (MS)
Document Type
Master's Thesis
College
Medicine
Department/School/Program
Medical Sciences
First Advisor
Dr. Jessica Blackburn
Abstract
Vascular endothelial growth factor (VEGF) is a signaling protein involved in inducing and regulating endothelial cell proliferation and function (Duffy et al 2000). VEGF is also involved in cancer progression, as it induces vascular permeability and promotes angiogenesis to tumor laden areas, giving cancer cells critical oxygen and nutrients (Hoeppner et al.,2012. Studies indicate VEGF prevents lymphoblast apoptosis, which may contribute to leukemia formation and enable the proliferation of leukemic cells (Duffy et al 2000). Ongoing research seeks to further examine VEGF in leukemia, using a rag2:GFP-Myc expressing transgenic zebrafish as the animal model of T-cell Acute Lymphoblastic Leukemia (T-ALL). Recent findings have concluded a relationship between VEGF expression in leukemic fish remodels the microenvironment leading to cell migration, but not through vascular restructuring, as a means to upregulate leukemic expression.
Digital Object Identifier (DOI)
https://doi.org/10.13023/etd.2021.093
Funding Information
This research was funded by the National Institutes of Health Director’s Fund, grant number DP2CA22804, between 9/1/17 to 5/30/22.
Recommended Citation
Powell, Shaw, "THE ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN LEUKEMIA TRAFFICKING" (2021). Theses and Dissertations--Medical Sciences. 15.
https://uknowledge.uky.edu/medsci_etds/15
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Biochemical Phenomena, Metabolism, and Nutrition Commons, Biological Phenomena, Cell Phenomena, and Immunity Commons, Medical Biochemistry Commons, Medical Cell Biology Commons, Medical Genetics Commons
