Author ORCID Identifier
Date Available
11-25-2022
Year of Publication
2020
Degree Name
Master of Science (MS)
Document Type
Master's Thesis
College
Medicine
Department/School/Program
Medical Sciences
First Advisor
Dr. Greg A. Gerhardt
Abstract
Objective: Novel drug 419 was examined to see the effect it has in vivo mice and rats on alcohol consumption, nicotine locomotor sensitization, and conditioned place preference (CPP) models regarding behavioral tests on dopamine transporter activity.
Methods: Mice and rats were used to see how they react to the drug 419 and control vehicle, in each of the models. The animals were assessed to pre- and post- drug administration of novel drug 419. We examined each model to see the association between how drug 419 will help with treating drug abuse.
Results: We found that in alcohol consumption model the mice did not react well to drug 419 and had no significant results. In the nicotine locomotor sensitization, we found that drug 419 has potential in reversing the nicotine induced locomotor activity and could help reduce nicotine abusive disorder. The CPP model did not have any significant results in either rat group. We found that drug 419 at the dose we administered does not seem to have a significant effect in the mesolimbic dopaminergic pathways and may not facilitate a role in treating drug abuse.
Conclusion: Our findings suggest that drug 419 may play a role in only nicotine locomotor sensitization due to the reversal of nicotine induce LMA that was observed. The use of drug 419 in alcohol consumption and CPP models indicated that it is not effective as it did not alter the behavior in mice and rats. The need for understanding the pharmacological and pharmacokinetics of drug 419 is critical to fully be implemented in future behavioral tests.
Digital Object Identifier (DOI)
https://doi.org/10.13023/etd.2020.438
Funding Information
This research was sponsored by Naprogenix Inc. UK-ASTECC 145 Graham Avenue Lexington, KY 40506-0286 in 2019.
Grant Number: 3R44AA025804-02S1
Project Title: Mutant transgenic plant cells as a novel source of drugs
Recommended Citation
Suhail, Cocanut M., "MEASURING THE EFFECTS OF LOBINALINE-N-BIOXIDE (419) ON ALCOHOL CONSUMPTION, NICOTINE LOCOMOTOR SENSITIZATION, AND CONDITIONED PLACE PREFERENCE IN MICE AND RATS" (2020). Theses and Dissertations--Medical Sciences. 13.
https://uknowledge.uky.edu/medsci_etds/13
Included in
Animal Experimentation and Research Commons, Behavioral Disciplines and Activities Commons, Behavior and Behavior Mechanisms Commons, Biological Psychology Commons, Chemical Actions and Uses Commons, Medical Neurobiology Commons, Medical Pharmacology Commons, Medicinal and Pharmaceutical Chemistry Commons, Neurosciences Commons, Pharmaceutical Preparations Commons, Pharmaceutics and Drug Design Commons, Pharmacology Commons
