Abstract
Being the largest and most visible organ of the body and heavily influenced by environmental factors, skin is ideal to study the long-term effects of aging. Throughout our lifetime, we accumulate damage generated by UV radiation. UV causes inflammation, immune changes, physical changes, impaired wound healing and DNA damage that promotes cellular senescence and carcinogenesis. Melanoma is the deadliest form of skin cancer and among the malignancies of highest increasing incidence over the last several decades. Melanoma incidence is directly related to age, with highest rates in individuals over the age of 55 years, making it a clear age-related disease. In this review, we will focus on UV-induced carcinogenesis and photo aging along with natural protective mechanisms that reduce amount of "realized" solar radiation dose and UV-induced injury. We will focus on the theoretical use of forskolin, a plant-derived pharmacologically active compound to protect the skin against UV injury and prevent aging symptoms by up-regulating melanin production. We will discuss its use as a topically-applied root-derived formulation of the Plectranthus barbatus (Coleus forskolii) plant that grows naturally in Asia and that has long been used in various Aryuvedic teas and therapeutic preparations.
Document Type
Article
Publication Date
5-15-2014
Digital Object Identifier (DOI)
http://dx.doi.org/10.3390/molecules19056202
Funding Information
This work was supported by grants: RO1CA131075 and supplemental RO1CA131075-02S1 from the National Cancer Institute. NIH: UL1TR000117, TL1 TR000115, KL2 TR000116 National Center for Advancing Translational Sciences University of Kentucky.
Repository Citation
Amaro-Ortiz, Alexandra; Yan, Betty; and D’Orazio, John A., "Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by Topical cAMP Manipulation" (2014). Markey Cancer Center Faculty Publications. 46.
https://uknowledge.uky.edu/markey_facpub/46
Notes/Citation Information
Published in Molecules, v. 19, no. 5, p. 6202-6219.
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).