Abstract
We estimated the population-level incidence of human papillomavirus (HPV)–positive oropharyngeal, cervical, and anal cancers by smoking status. We combined HPV DNA genotyping data from the Centers for Disease Control and Prevention’s Cancer Registry Sentinel Surveillance System with data from the Kentucky Cancer Registry and Behavioral Risk Factor Surveillance System across smoking status. During 2004-2005 and 2014-2015 in Kentucky, most cases of oropharyngeal (63.3%), anal (59.7%), and cervical (54.9%) cancer were among individuals who ever smoked. The population-level incidence rate was higher among individuals who ever smoked than among those who never smoked for HPV-positive oropharyngeal (7.8 vs 2.1; adjusted incidence rate ratio ¼ 2.6), cervical (13.7 vs 6.8; adjusted incidence rate ratio ¼ 2.0), and anal (3.9 vs 1.6; adjusted incidence rate ratio ¼ 2.5) cancers. These findings indicate that smoking is associated with increased risk of HPV-positive oropharyngeal, cervical, and anal cancers, and the population-level burden of these cancers is higher among individuals who ever smoked.
Document Type
Article
Publication Date
2024
Digital Object Identifier (DOI)
https://doi.org/10.1093/jnci/djae054
Funding Information
Not applicable.
Repository Citation
Gopalani, Sameer V.; Saraiya, Mona; Huang, Bin; Tucker, Thomas; Mix, Jacqueline M.; and Chaturvedi, Anil K., "Population-level incidence of human papillomavirus–positive oropharyngeal, cervical, and anal cancers, by smoking status" (2024). Markey Cancer Center Faculty Publications. 457.
https://uknowledge.uky.edu/markey_facpub/457
Notes/Citation Information
Published by Oxford University Press 2024. This work is written by (a) US Government employee(s) and is in the public domain in the US.