Abstract
BACKGROUND: Patients with advanced chronic kidney disease (ACKD) are at an increased risk of developing renal cell carcinoma (RCC), but molecular alterations in RCC specimens arising from ACKD and overall survival (OS) in affected patients are not well defined.
PATIENTS AND METHODS: Using the Oncology Research Information Exchange Network (ORIEN) Total Cancer Care
RESULTS: Of 296 patients with RCC, 61 met the criteria for ACKD. The most common somatic mutations in the overall cohort were in
CONCLUSIONS: Using the clinicogenomic ORIEN database, our study found lower rates of
Document Type
Article
Publication Date
5-18-2024
Digital Object Identifier (DOI)
https://doi.org/10.3390/cancers16101920
Funding Information
This study was supported by the University of Colorado Cancer Center Support Grant P30CA046934.
Repository Citation
Eule, Corbin J.; Hu, Junxiao; Hedges, Dale; Jani, Alkesh; Pshak, Thomas; Manley, Brandon J.; Sanchez, Alejandro; Dreicer, Robert; Myint, Zin W.; Zakharia, Yousef; and Lam, Elaine T., "Clinical and Genomic Features of Patients with Renal Cell Carcinoma and Advanced Chronic Kidney Disease: Analysis of a Multi-Institutional Database." (2024). Markey Cancer Center Faculty Publications. 444.
https://uknowledge.uky.edu/markey_facpub/444
Notes/Citation Information
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).