Rufus Akinyemi, University of Ibadan, Nigeria
Donna K. Arnett, University of KentuckyFollow
Hemant K. Tiwari, The University of Alabama at Birmingham
Bruce Ovbiagele, Medical University of South Carolina
Fred Sarfo, Kwame Nkrumah University of Science and Technology, Ghana
Vinodh Srinivasasainagendra, The University of Alabama at Birmingham
Marguerite Ryan Irvin, The University of Alabama at Birmingham
Abiodun Adeoye, University of Ibadan, Nigeria
Rodney T. Perry, The University of Alabama at Birmingham
Albert Akpalu, University of Ghana, Ghana
Carolyn Jenkins, Medical University of South Carolina
Lukman Owolabi, Aminu Kano Teaching Hospital, Nigeria
Reginald Obiako, Ahmadu Bello University, Nigeria
Kolawole Wahab, University of Ilorin, Nigeria
Emmanuel Sanya, University of Ilorin, Nigeria
Morenikeji Komolafe, Obafemi Awolowo University, Nigeria
Michael Fawale, Obafemi Awolowo University, Nigeria
Philip Adebayo, Ladoke Akintola University of Technology Nigeria
Godwin Osaigbovo, University of Jos, Nigeria
Taofiki Sunmonu, Federal Medical Centre, Nigeria
Paul Olowoyo, Federal University Teaching Hospital Ido-Ekiti, Nigeria
Innocent Chukwuonye, Federal Medical Centre, Nigeria
Yahaya Obiabo, Delta State University, Nigeria
Onoja Akpa, University of Ibadan, Nigeria
Sylvia Melikam, University of Ibadan, Nigeria
Raelle Saulson, Medical University of South Carolina
Raj Kalaria, Newcastle University, UK
Adesola Ogunniyi, University of Ibadan, Nigeria
Mayowa Owolabi, University of Ibadan, Nigeria


Background—Inherited genetic variations offer a possible explanation for the observed peculiarities of stroke in sub – Saharan African populations. Interleukin–6 polymorphisms have been previously associated with ischemic stroke in some non-African populations.

Aim—Herein we investigated, for the first time, the association of genetic polymorphisms of IL-6 and CDKN2A- CDKN2B and other genes with ischemic stroke among indigenous West African participants in the Stroke Investigative Research and Education Network (SIREN) Study.

Methods—Twenty-three previously identified single nucleotide polymorphisms (SNPs) in 14 genes of relevance to the neurobiology of ischemic stroke were investigated. Logistic regression models adjusting for known cardiovascular disease risk factors were constructed to assess the associations of the 24 SNPs in rigorously phenotyped cases (N=429) of ischemic stroke (Men = 198; Women = 231) and stroke– free (N=483) controls (Men = 236; Women = 247).

Results—Interleukin-6 (IL6) rs1800796 (C minor allele; frequency: West Africans = 8.6%) was significantly associated with ischemic stroke in men (OR = 2.006, 95% CI = [1.065, 3.777], p = 0.031) with hypertension in the model but not in women. In addition, rs2383207 in CDKN2A/CDKN2B (minor allele A with frequency: West Africans = 1.7%) was also associated with ischemic stroke in men (OR = 2.550, 95% CI = [1.027, 6.331], p = 0.044) with primary covariates in the model, but not in women. Polymorphisms in other genes did not show significant association with ischemic stroke.

Conclusion—Polymorphisms rs1800796 in IL6 gene and rs2383207 in CDKN2A/CDKN2B gene have significant associations with ischemic stroke in indigenous West African men. CDKN2A/CDKN2B SNP rs2383207 is independently associated with ischemic stroke in indigenous West African men. Further research should focus on the contributions of inflammatory genes and other genetic polymorphisms, as well as the influence of sex on the neurobiology of stroke in people of African ancestry.

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Notes/Citation Information

Published in Journal of the Neurological Sciences, v. 379, p. 229-235.

© 2017 Elsevier B.V. All rights reserved.

This manuscript version is made available under the CC‐BY‐NC‐ND 4.0 license

The document available for download is the author's post-peer-review final draft of the article.

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Funding Information

The SIREN project is supported by U54HG007479 from the National Institutes of Health (NIH) as part of the H3Africa Consortium.

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