Abstract
INTRODUCTION: Post-traumatic stress disorder (PTSD) is associated with an increased risk of dementia. Individual epidemiological studies have controlled for several confounders of the relationship between PTSD and increased dementia risk, yet particular risk factors underlying this relationship have not been determined. This systematic review protocol aims to identify risk and protective factors of dementia among adults with PTSD.
METHODS AND ANALYSIS: We will conduct an electronic search of the databases: PubMed, CINAHL, PsychINFO, The Cochrane Library, Scopus and ProQuest Dissertation and Theses Global. After screening the studies, quantitative synthesis will be performed, if possible. Otherwise, a narrative synthesis will be performed. We will include randomised controlled trials and other types of research evidence including longitudinal cohort studies. Strength of evidence will be assessed using the Grading of Recommendations, Assessment, Development and Evaluations method. Examples of variables that will be extracted are: year of PTSD diagnosis, comorbid conditions, health behaviours, pharmacological treatments and year of mild cognitive impairment or dementia diagnosis. We developed this systematic review protocol according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 statement.
ETHICS AND DISSEMINATION: The proposed study will not collect individual-level data and, therefore, does not require ethical approval. Results of this study will provide current evidence on risk and protective factors of dementia in adults with PTSD. Findings will be disseminated in peer-reviewed publications and conference presentations.
PROSPERO REGISTRATION NUMBER: CRD42019128553.
Document Type
Article
Publication Date
6-3-2020
Digital Object Identifier (DOI)
https://doi.org/10.1136/bmjopen-2019-035517
Funding Information
The work was supported by the Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) grant (#5K12DA035150) from the Office of Research on Women’s Health (ORWH) and National Institute on Drug Abuse (NIDA) at the National Institutes of Health (NIH).
Repository Citation
Lawrence, Karen A.; Pachner, Theresia M.; Long, Molly M.; Henderson, Stephanie; Schuman, Donna L.; and Plassman, Brenda L., "Risk and Protective Factors of Dementia Among Adults With Post-Traumatic Stress Disorder: A Systematic Review Protocol" (2020). Social Work Faculty Publications. 3.
https://uknowledge.uky.edu/csw_facpub/3
Notes/Citation Information
Published in BMJ Open, v. 10, issue 6, p. 1-5.
© Author(s) (or their employer(s)) 2020
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