Neurocognitive Basis of Repetition Deficits in Primary Progressive Aphasia

Authors

Sladjana Lukic, University of California, San Francisco
Maria Luisa Mandelli, University of California, San Francisco
Ariane Welch, University of California, San Francisco
Kesshi Jordan, University of California, San Francisco
Wendy Shwe, University of California, San Francisco
John Neuhaus, University of California, San Francisco
Zachary Miller, University of California, San Francisco
H. Isabel Hubbard, University of KentuckyFollow
Maya Henry, University of Texas, Austin
Bruce L. Miller, University of California, San Francisco
Nina F. Dronkers, University of California, Berkeley
Maria Luisa Gorno-Tempini, University of California, San Francisco

Abstract

Previous studies indicate that repetition is affected in primary progressive aphasia (PPA), particularly in the logopenic variant, due to limited auditory-verbal short-term memory (avSTM). We tested repetition of phrases varied by length (short, long) and meaning (meaningful, non-meaningful) in 58 participants (22 logopenic, 19 nonfluent, and 17 semantic variants) and 21 healthy controls using a modified Bayles repetition test. We evaluated the relation between cortical thickness and repetition performance and whether sub-scores could discriminate PPA variants.

Logopenic participants showed impaired repetition across all phrases, specifically in repeating long phrases and any phrases that were non-meaningful. Nonfluent, semantic, and healthy control participants only had difficulty repeating long, non-meaningful phrases. Poor repetition of long phrases was associated with cortical thinning in left temporo-parietal areas across all variants, highlighting the importance of these areas in avSTM. Finally, Bayles repetition phrases can assist classification in PPA, discriminating logopenic from nonfluent/semantic participants with 89% accuracy.

Document Type

Article

Publication Date

7-2019

Notes/Citation Information

Published in Brain and Language, v. 194.

© 2019 Elsevier Inc.

© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/

Digital Object Identifier (DOI)

https://doi.org/10.1016/j.bandl.2019.04.003

Funding Information

This work was supported by the National Institutes of Health (M.L.GT., NINDS R01 NS050915, NIDCD K24 DC015544; NIA U01 AG052943; M.H., R01DC016291–02; B.L.M., NIA P50 AG03006, NIA P50 AG023501, NIA P01 AG019724; N.D. NIDCD RO1 DC016345); State of California (M.L.GT., DHS04–35516); Alzheimer’s Disease Center of California (B.L.M., 03–75271 DHS/ADP/ARCC); John Douglas French Alzheimer’s Foundation (B.L.M.); Koret Family Foundation; The Bluefield Project to Cure Frontotemporal Dementia (B.L.M.); and McBean Family Foundation (B.L.M.).

Repository Citation

Lukic, Sladjana; Mandelli, Maria Luisa; Welch, Ariane; Jordan, Kesshi; Shwe, Wendy; Neuhaus, John; Miller, Zachary; Hubbard, H. Isabel; Henry, Maya; Miller, Bruce L.; Dronkers, Nina F.; and Gorno-Tempini, Maria Luisa, "Neurocognitive Basis of Repetition Deficits in Primary Progressive Aphasia" (2019). Communication Sciences and Disorders Faculty Publications. 2.
https://uknowledge.uky.edu/csd_facpub/2