CRVAW Faculty Journal Articles
Archived
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Adeno-Associated Virus Is Associated with a Lower Risk of High-Grade Cervical Neoplasia
Abstract
Adeno-associated virus (AAV) is a ubiquitous human helper-dependent parvovirus which may interact with human papillomaviruses (HPV) to modify a woman's risk of cervical neoplasia. This analysis was nested in a cohort study of low-income women receiving Pap smears as part of their family planning services. We selected cases (55 with high-grade cervical squamous intraepithelial lesions (HSIL) and 162 with low-grade LSIL) and controls (96 women with normal cervical cytology) and analyzed cervical DNA for AAV, using PCR amplification/dot blot hybridization, and HPV, using hybrid capture I. AAV positivity was associated with a significantly reduced risk of HSIL (age and HPV-adjusted odds ratio (aOR) = 0.32) yet not with LSIL (aOR = 0.78); 53.8% of HSIL, 66.9% of LSIL, and 70.7% of controls were AAV+. AAV appears to interact with HPV to reduce SIL risk; relative to the HPV−/AAV+ exposure, the respective aORs for HSIL and HPV+/AAV−, HPV+/AAV+, and HPV−/AAV+ were 17.0, 6.9, and 3.5. AAV+ was not associated with age, race, HPV status, or sexual or reproductive risk factors. These results strongly suggest that AAV may play a protective or inhibitory role in late stage cervical carcinogenesis. This conclusion needs to be verified in additional epidemiologic studies.
Document Type
Article
Publication Date
4-2001
Digital Object Identifier (DOI)
http://dx.doi.org/10.1006/exmp.2000.2347
Repository Citation
Coker, Ann L.; Russell, Rebecca B.; Bond, Sharon; Pirisi, Lucia; Liu, Yong; Mane, Michael; Kokorina, Natalia; Gerasimova, Tsilya; and Hermonat, Paul L., "Adeno-Associated Virus Is Associated with a Lower Risk of High-Grade Cervical Neoplasia" (2001). CRVAW Faculty Journal Articles. 232.
https://uknowledge.uky.edu/crvaw_facpub/232
Notes/Citation Information
Published in Experimental and Molecular Pathology, v. 70, no. 2, p. 83-89.
Dr. Ann Coker had not been a faculty member of the University of Kentucky at the time of publication.