Hormonal and Barrier Methods of Contraception, Oncogenic Human Papillomaviruses, and Cervical Squamous Intraepithelial Lesion Development

Authors

Ann L. Coker, University of South Carolina - ColumbiaFollow
Laura C. Sanders, South Carolina Department of Health and Environmental Control
Sharon M. Bond, Medical University of South CarolinaFollow
Tsilya Gerasimova, University of South Carolina - ColumbiaFollow
Lucia Pirisi, University of South CarolinaFollow

Abstract

We assessed the influence of hormonal (oral, injectable, or levonorgestrel [Norplant, Wyeth-Ayerst, Philadelphia, PA]) and barrier methods of contraception on the risk of cervical squamous intraepithelial lesions (SIL), while adjusting for high-risk (HR) HPV infection. Subjects were women receiving family planning services through the state health department clinics from 1995 to 1998. We selected 60 cases with high-grade cervical/SIL (HSIL) and 316 with low-grade cervical/SIL (LSIL) and controls (427 women with normal cervical cytology) and analyzed cervical DNA for HR-HPV, using Hybrid Capture I (Digene; Gaithersburg, MD).When assessing ever use, duration, recency, latency, and age at first use, neither oral contraceptives (OC), Norplant, nor injectable use was associated with an increased risk of SIL development after adjusting for age, age at first sexual intercourse, and HR-HPV positivity. Among HR-HPV-positive women, longer duration barrier method use was associated with a reduced risk of SIL. This finding has important clinical implications for SIL prevention among HR-HPV-infected women.

Document Type

Article

Publication Date

2001

Notes/Citation Information

Published in Journal of Women's Health & Gender-Based Medicine, v. 10, no. 5, p. 441-449.

This is a copy of an article published in the Journal of Women's Health & Gender-Based Medicine © 2001 Mary Ann Liebert, Inc.; Journal of Women's Health & Gender-Based Medicine is available online at: http://online.liebertpub.com/loi/jwh.1

Dr. Ann Coker had not been a faculty member of the University of Kentucky at the time of publication.

Digital Object Identifier (DOI)

http://dx.doi.org/10.1089/152460901300233911

Repository Citation

Coker, Ann L.; Sanders, Laura C.; Bond, Sharon M.; Gerasimova, Tsilya; and Pirisi, Lucia, "Hormonal and Barrier Methods of Contraception, Oncogenic Human Papillomaviruses, and Cervical Squamous Intraepithelial Lesion Development" (2001). CRVAW Faculty Journal Articles. 114.
https://uknowledge.uky.edu/crvaw_facpub/114