CRVAW Faculty Journal Articles
Oral Contraceptive Use and Cervical Intraepithelial Neoplasia
Abstract
To explore the somewhat controversial relationship between oral contraceptives and and-invasive cervical cancer, 103 cases of biopsy-confirmed cervical intraepithelial neoplasia (CIN) II or CIN III were compared with 258 controls who had normal cervical cytology. Cases were slightly less likely than controls to have ever used oral contraceptives; the odds ratio, controlling for age, socioeconomic status, barrier method use, smoking history, age at first sexual intercourse, number of sex partners, current marital status, and number of Pap smears, was 0.7 (95% CI 0.3–1.6). Recency, latency, duration, and age at first oral contraceptive use were evaluted and in no instance was oral contraceptive use positively associated with CIN. This study adds to the body of knowledge that oral contraceptives are not associated with pre-invasive cervical cancer. Further, if oral contraceptive users continue to be regularly screened, their risk of developing the more invasive lesions should be very low.
Document Type
Article
Publication Date
10-1992
Digital Object Identifier (DOI)
http://dx.doi.org/10.1016/0895-4356(92)90151-C
Repository Citation
Coker, Ann L.; McCann, Margaret F.; Hulka, Barbara S.; and Walton, Leslie A., "Oral Contraceptive Use and Cervical Intraepithelial Neoplasia" (1992). CRVAW Faculty Journal Articles. 225.
https://uknowledge.uky.edu/crvaw_facpub/225
Notes/Citation Information
Published in Journal of Clinical Epidemiology, v. 45, no. 10, p. 1111-1118.
Dr. Ann Coker had not been a faculty member of the University of Kentucky at the time of publication.