Active and Passive Cigarette Smoke Exposure and Cervical Intraepithelial Neoplasia

Authors

Ann L. Coker, University of South Carolina - ColumbiaFollow
Allison J. Rosenberg, University of South Carolina - ColumbiaFollow
Margaret F. McCann, University of North Carolina at Chapel HillFollow
Barbara S. Hulka, University of North Carolina at Chapel HillFollow

Abstract

This case-control analysis presents odds ratios for active and passive cigarette smoke exposure and cervical intraepithelial neoplasia of levels II and III (CIN II and CIN III) while controlling for confounders. From 1987 to 1988, 103 biopsy-conformed incident cases of CIN II or III and 268 controls with normal cervical cytology were enrolled. Seventy % of cases were cigarette smokers, while only 30% of controls had ever smoked. The adjusted odds ratio for current cigarette smoking was 3.4 (95% confidence interval, 1.7-7.0). The following confounders were included in logistic regression models: age, race, education, number of sex partners, contraceptive use, sexually transmitted disease history, and Pap smear history. The risk of CIN II/III increased with increasing years of cigarette smoking and with increasing pack-years of exposure. Smoking was associated more strongly with CIN III than CIN II. The effect of passive cigarette smoke exposure was explored separately for smokers and nonsmokers and was found not to be consistently associated with CIN II/III when controlling for confounders.

Document Type

Article

Publication Date

7-1992

Notes/Citation Information

Published in Cancer Epidemiology, Biomarkers & Prevention, v. 1, no. 5, p. 349-356.

Dr. Ann Coker had not been a faculty member of the University of Kentucky at the time of publication.

Repository Citation

Coker, Ann L.; Rosenberg, Allison J.; McCann, Margaret F.; and Hulka, Barbara S., "Active and Passive Cigarette Smoke Exposure and Cervical Intraepithelial Neoplasia" (1992). CRVAW Faculty Journal Articles. 223.
https://uknowledge.uky.edu/crvaw_facpub/223