Abstract
The efficacy of a novel synthetic antimicrobial peptide (WLBU2) was evaluated against three oral microorganisms (grown planktonically): Streptococcus gordonii, Fusobacterium nucleatum, and Porphyromonas gingivalis. WLBU2 killed all three species, with F. nucleatum being the most susceptible. WLBU2 also reduced the bacterial burden of S. gordonii and F. nucleatum biofilms.
Document Type
Article
Publication Date
5-2007
Digital Object Identifier (DOI)
http://dx.doi.org/10.1128/AAC.00924-06
Funding Information
This work was supported by a University of Kentucky research support grant and by Kentucky Science and Technology Corporation/Kentucky Science and Engineering Foundation grant KSEF-47-RDE-004.
Repository Citation
Novak, Karen F.; Diamond, William J.; Kirakodu, Sreenatha S.; Peyyala, Rebecca; Anderson, Kimberly W.; Montelaro, Ronald C.; and Mietzner, Timothy A., "Efficacy of the De Novo-Derived Antimicrobial Peptide WLBU2 against Oral Bacteria" (2007). Center for Oral Health Research Faculty Publications. 3.
https://uknowledge.uky.edu/cohr_facpub/3
Notes/Citation Information
Published in Antimicrobial Agents and Chemotherapy, v. 51, no. 5, p. 1837–1839.
Copyright © 2007, American Society for Microbiology. All Rights Reserved.
The copyright holders have granted the permission for posting the article here.