Abstract
This review considers fully three-dimensional biomaterial environments of varying complexity as these pertain to research on the placenta. The developments in placental cell sources are first considered, along with the corresponding maternal cells with which the trophoblast interact. We consider biomaterial sources, including hybrid and composite biomaterials. Properties and characterization of biomaterials are discussed in the context of material design for specific placental applications. The development of increasingly complicated three-dimensional structures includes examples of advanced fabrication methods such as microfluidic device fabri- cation and 3D bioprinting, as utilized in a placenta context. The review finishes with a discussion of the potential for in vitro, three-dimensional placenta research to address health disparities and sexual dimorphism, especially in light of the exciting recent changes in the regulatory environment for in vitro devices.
Document Type
Article
Publication Date
11-2024
Digital Object Identifier (DOI)
https://doi.org/10.1016/j.placenta.2024.03.006
Funding Information
This research was funded by T32 Clinical Outcomes Research Training Program in Female Lower Urinary Tract Disorders NIH T32DK120497 (SGZ). The authors would also like to acknowledge the NIH T32 Postdoctoral Training Grant in Regenerative Medicine (T32 EB028092) for additional research support (AKS). Figures created with BioRender.com.
Repository Citation
Zambuto, Samantha G.; Scott, Adrienne K.; and Oyen, Michelle L., "Beyond 2D: Novel biomaterial approaches for modeling the placenta" (2024). Biomedical Engineering Faculty Publications. 49.
https://uknowledge.uky.edu/cbme_facpub/49
Notes/Citation Information
0143-4004/© 2024 Elsevier Ltd. All rights reserved.