Abstract

We report a low-cost compact diffuse speckle contrast flowmeter (DSCF) consisting of a small laser diode and a bare charge-coupled-device (CCD) chip, which can be used for contact measurements of blood flow variations in relatively deep tissues (up to ∼8  mm). Measurements of large flow variations by the contact DSCF probe are compared to a noncontact CCD-based diffuse speckle contrast spectroscopy and a standard contact diffuse correlation spectroscopy in tissue phantoms and a human forearm. Bland–Altman analysis shows no significant bias with good limits of agreement among these measurements: 96.5% ± 2.2% (94.4% to 100.0%) in phantom experiments and 92.8% in the forearm test. The relatively lower limit of agreement observed in the in vivo measurements (92.8%) is likely due to heterogeneous reactive responses of blood flow in different regions/volumes of the forearm tissues measured by different probes. The low-cost compact DSCF device holds great potential to be broadly used for continuous and longitudinal monitoring of blood flow alterations in ischemic/hypoxic tissues, which are usually associated with various vascular diseases.

Document Type

Article

Publication Date

8-8-2016

Notes/Citation Information

Published in Journal of Biomedical Optics, v. 21, no. 8, 080501, p. 1-4.

Chong Huang, Myeongsu Seong, Joshua Paul Morgan, Siavash Mazdeyasna, Jae Gwan Kim, Jeffrey Todd Hastings, Guoqiang Yu, "Low-cost compact diffuse speckle contrast flowmeter using small laser diode and bare charge-coupled-device," Journal of Biomedical Optics 21(8), 080501 (August 8, 2016). http://dx.doi.org/10.1117/1.JBO.21.8.080501

Copyright 2016 Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

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Digital Object Identifier (DOI)

https://doi.org/10.1117/1.JBO.21.8.080501

Funding Information

The authors acknowledge funding support from the National Institutes of Health (NIH) R01-CA149274 (G. Yu) and R21- AR062356 (G. Yu). We also acknowledge the support from UKY Reese S. Terry professorship (J. T. Hastings), Global PhD Fellowship Program NRF-2015H1A2A1032268 (M. Seong) and the Department of Biomedical Science and Engineering in the Gwangju Institute of Science and Technology (J. G. Kim), Republic of Korea.

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