Abstract
In vertebrates, many cytokines and growth factors have been identified as activators of the JAK/STAT signaling pathway. In Drosophila, JAK and STAT molecules have been isolated, but no ligands or receptors capable of activating the pathway have been described. We have characterized the unpaired (upd) gene, which displays the same distinctive embryonic mutant defects as mutations in the Drosophila JAK (hopscotch) and STAT (stat92E) genes. Upd is a secreted protein, associated with the extracellular matrix, that activates the JAK pathway. We propose that Upd is a ligand that relies on JAK signaling to stimulate transcription of pair-rule genes in a segmentally restricted manner in the early Drosophila embryo.
Document Type
Article
Publication Date
10-15-1998
Digital Object Identifier (DOI)
http://dx.doi.org/10.1101/gad.12.20.3252
Repository Citation
Harrison, Douglas A.; McCoon, Patricia E.; Binari, Richard; Gilman, Michael; and Perrimon, Norbert, "Drosophila Unpaired Encodes a Secreted Protein that Activates the JAK Signaling Pathway" (1998). Biology Faculty Publications. 88.
https://uknowledge.uky.edu/biology_facpub/88
Notes/Citation Information
Published in Genes & Development, v. 12, no. 20, p. 3252-3263.
© 1998 by Cold Spring Harbor Laboratory Press
This article is available under a Creative Commons License (Attribution-NonCommercial 4.0 International License) after six months from the full-issue publication date.