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Submissions from 2016

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Structures of EccB1 and EccD1 from the Core Complex of the Mycobacterial ESX-1 Type VII Secretion System, Jonathan Mark Wagner, Sum Chan, Timothy J. Evans, Sara Kahng, Jennifer Kim, Mark A. Arbing, David Eisenberg, and Konstantin V. Korotkov

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Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor Cell Invasion via Inhibition of Hippo Pathway, Yifan Wang, Jingyi Liu, Xuhua Ying, Pengnian Charles Lin, and Binhua P. Zhou

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Pleckstrin Homology (PH) Domain Leucine-Rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C, Xiaopeng Xiong, Xin Li, Yang-An Wen, and Tianyan Gao

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KLF4 Deletion Alters Gastric Cell Lineage and Induces MUC2 Expression, Tianxin Yu, Xi Chen, T. Lin, J. Liu, M. Li, W. Zhang, X. Xu, W. Zhao, M. Liu, Dana L. Napier, Chi Wang, B. Mark Evers, and Chunming Liu

Submissions from 2015

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Linker Histone H1 and H3K56 Acetylation are Antagonistic Regulators of Nucleosome Dynamics, Morgan Bernier, Yi Luo, Kingsley C. Nwokelo, Michelle Goodwin, Sarah J. Dreher, Pei Zhang, Mark R. Parthun, Yvonne N. Fondufe-Mittendorf, Jennifer J. Ottesen, and Michael G. Poirier

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Integrin α6β4 Promotes Autocrine Epidermal Growth Factor Receptor (EGFR) Signaling to Stimulate Migration and Invasion toward Hepatocyte Growth Factor (HGF), Brittany L. Carpenter, Min Chen, Teresa Knifley, Kelley A. Davis, Susan M.W. Harrison, Rachel L. Stewart, and Kathleen O'Connor

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Analysis of Cathepsin and Furin Proteolytic Enzymes Involved in Viral Fusion Protein Activation in Cells of the Bat Reservoir Host, Farah El Najjar, Levi Lampe, Michelle L. Baker, Lin-Fa Wang, and Rebecca Ellis Dutch

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Differential Impact of LPG-and PG-Deficient Leishmania major Mutants on the Immune Response of Human Dendritic Cells, Michelle A. Favila, Nicholas S. Geraci, Asha Jayakumar, Suzanne Hickerson, Janet Mostrom, Salvatore J. Turco, Stephen M. Beverley, and Mary Ann McDowell

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PP2A Inhibitors Arrest G2/M Transition Through JNK/Sp1-Dependent Down-Regulation of CDK1 and Autophagy-Dependent Up-Regulation of p21, Fei-Ran Gong, Meng-Yao Wu, Meng Shen, Qiaoming Zhi, Ze-Kuan Xu, Rong Wang, Wen-Jie Wang, Yang Zong, Zeng-Liang Li, Yadi Wu, Binhua P. Zhou, Kai Chen, Min Tao, and Wei Li

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The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells, Hanjun Guan, K. Martin Chow, Eunsuk Song, Nirmal Verma, Florin Despa, and Louis B. Hersh

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Preventing Farnesylation of the Dynein Adaptor Spindly Contributes to the Mitotic Defects Caused by Farnesyltransferase Inhibitors, Andrew J. Holland, Rita M. Reis, Sherry Niessen, Cláudia Pereira, Douglas A. Andres, H. Peter Spielmann, Don W. Cleveland, Arshad Desai, and Reto Gassmann

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Drug Synergy Drives Conserved Pathways to Increase Fission Yeast Lifespan, Xinhe Huang, Markos Leggas, and Robert C. Dickson

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Intra-Domain Cross-Talk Regulates Serine-Arginine Protein Kinase 1-Dependent Phosphorylation and Splicing Function of Transformer 2β1, Michael A. Jamros, Brandon E. Aubol, Malik M. Keshwani, Zhaiyi Zhang, Stefan Stamm, and Joseph A. Adams

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Chemoselective Detection and Discrimination of Carbonyl-Containing Compounds in Metabolite Mixtures by 1H-Detected 15N Nuclear Magnetic Resonance, Andrew N. Lane, Sengodagounder Arumugam, Pawel Lorkiewicz, Richard M. Higashi, Sébastien Laulhé, Michael H. Nantz, Hunter N. B. Moseley, and Teresa W-M Fan

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Determining the Role of IL-4 Induced Neuroinflammation in Microglial Activity and Amyloid-ß Using BV2 Microglial Cells and APP/PS1 Transgenic Mice, Clare H. Latta, Tiffany L. Sudduth, Erica M. Weekman, Holly M. Brothers, Erin L. Abner, Gabriel J. Popa, Michael D. Mendenhall, Floracita Gonzalez-Oregon, Kaitlyn Braun, and Donna M. Wilcock

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G9a Is Essential for EMT-Mediated Metastasis and Maintenance of Cancer Stem Cell-Like Characters in Head and Neck Squamous Cell Carcinoma, Shuli Liu, Dongxia Ye, Wenzheng Guo, Wenwen Yu, Yue He, Jingzhou Hu, Yanan Wang, Ling Zhang, Yueling Liao, Hongyong Song, Shuangshuang Zhong, Dongliang Xu, Huijing Yin, Beibei Sun, Xiaofei Wang, Jingyi Liu, Yadi Wu, Binhua P. Zhou, Zhiyuan Zhang, and Jiong Deng

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Transcriptional Activity of the Islet β Cell Factor Pdx1 Is Augmented by Lysine Methylation Catalyzed by the Methyltransferase Set7/9, Aarthi V. Maganti, Bernhard Maier, Sarah A. Tersey, Megan L. Sampley, Amber L. Mosley, Sabire Özcan, Boobalan Pachaiyappan, Patrick M. Woster, Chad S. Hunter, Roland Stein, and Raghavendra G. Mirmira

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Mechanistic Insights into Glucan Phosphatase Activity against Polyglucan Substrates, David A. Meekins, Madushi Raththagala, Kyle D. Auger, Benjamin D. Turner, Diana Santelia, Oliver Kötting, Matthew S. Gentry, and Craig W. Vander Kooi

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Genome-Wide Profiling of PARP1 Reveals an Interplay with Gene Regulatory Regions and DNA Methylation, Narasimharao Nalabothula, Taha Al-Jumaily, Abdallah M. Eteleeb, Robert M. Flight, Shao Xiaorong, Hunter Moseley, Eric C. Rouchka, and Yvonne N. Fondufe-Mittendorf

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Autophagy Is Induced Upon Platelet Activation and Is Essential for Hemostasis and Thrombosis, Madhu M. Ouseph, Yunjie Huang, Meenakshi Banerjee, Smita Joshi, Laura MacDonald, Yu Zhong, Huijuan Liu, Xianting Li, Binggang Xiang, Guoying Zhang, Masaaki Komatsu, Zhenyu Yue, Zhenyu Li, Brian Storrie, Sidney W. Whiteheart, and Qing Jun Wang

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Structural Mechanism of Laforin Function in Glycogen Dephosphorylation and Lafora Disease, Madushi Raththagala, M. Kathryn Brewer, Matthew W. Parker, Amanda R. Sherwood, Brian K. Wong, Simon Hsu, Travis M. Bridges, Bradley C. Paasch, Lance M. Hellman, Satrio Husodo, David A. Meekins, Adam O. Taylor, Benjamin D. Turner, Kyle D. Auger, Vikas V. Dukhande, Srinivas Chakravarthy, Pascual Sanz, Virgil L. Woods Jr., Sheng Li, Craig Vander Kooi, and Matthew S. Gentry

Inorganic Arsenic-Induced Cellular Transformation is Coupled with Genome Wide Changes in Chromatin Structure, Transcriptome and Splicing Patterns, Caitlyn Riedmann, Ye Ma, Manana Melikishvili, Steven Grason Godfrey, Zhuo Zhang, Kuey-Chu Chen, Eric C. Rouchka, and Yvonne N. Fondufe-Mittendorf

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Deubiquitinase USP47/UBP64E Regulates β-Catenin Ubiquitination and Degradation and Plays a Positive Role in Wnt Signaling, Jiandang Shi, Yajuan Liu, Xuehe Xu, Wen Zhang, Tianxin Yu, Jianhang Jia, and Chunming Liu

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Pharmacodynamic Assays to Facilitate Preclinical and Clinical Development of Pre-mRNA Splicing Modulatory Drug Candidates, Yihui Shi, Amanda S. Joyner, William Shadrick, Gustavo Palacios, Chandraiah Lagisetti, Philip M. Potter, Lidia C. Sambucetti, Stefan Stamm, and Thomas R. Webb

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An Extended Polyanion Activation Surface in Insulin Degrading Enzyme, Eun Suk Song, Mehmet Ozbil, Tingting Zhang, Michael Sheetz, David Lee, Danny Tran, Sheng Li, Rajeev Prabhakar, Louis B. Hersh, and David W. Rodgers