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Submissions from 2012

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Structural Basis for Activation of Calcineurin by Calmodulin, Julie Rumi-Masante, Farai I. Rusinga, Terrence E. Lester, Tori B. Dunlap, Todd D. Williams, A. Keith Dunker, David D. Weis, and Trevor P. Creamer

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Active Site Mutations Change the Cleavage Specificity of Neprilysin., Travis Sexton, Lisa J. Hitchcook, David W. Rodgers, Luke H. Bradley, and Louis B. Hersh

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Beyond Anchoring: The Expanding Role of the Hendra Virus Fusion Protein Transmembrane Domain in Protein Folding, Stability, and Function, Everett Clinton Smith, Megan R. Culler, Lance M. Hellman, Michael G. Fried, Trevor P. Creamer, and Rebecca Ellis Dutch

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Role of Sequence and Structure of the Hendra Fusion Protein Fusion Peptide in Membrane Fusion, Everett Clinton Smith, Sonia M. Gregory, Lukas K. Tamm, Trevor P. Creamer, and Rebecca Ellis Dutch

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Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activation, Eun Suk Song, Manana Melikishvili, Michael G. Fried, Maria A. Juliano, Luiz Juliano, David W. Rodgers, and Louis B. Hersh

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C6 Pyridinium Ceramide Influences Alternative Pre-mRNA Splicing by Inhibiting Protein Phosphatase-1, Chiranthani Sumanasekera, Olga Kelemen, Monique Beullens, Brandon E. Aubol, Joseph A. Adams, Manjula Sunkara, Andrew J. Morris, Mathieu Bollen, Athena Andreadis, and Stefan Stamm

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Cooperative Cluster Formation, DNA Bending and Base-Flipping by O6-Alkylguanine-DNA Alkyltransferase, Ingrid Tessmer, Manana Melikishvili, and Michael G. Fried

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β-Secretases, Alzheimer's Disease, and Down Syndrome, Robin L. Webb and M. Paul Murphy

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Molecular characterization of the viaB locus encoding the biosynthetic machinery for Vi capsule formation in Salmonella Typhi, Michael Wetter, David Goulding, Derek Pickard, Michael Kowarik, Charles J. Waechter, Gordon Dougan, and Michael Wacker

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Medicinal Plants: A Public Resource for Metabolomics and Hypothesis Development, Eve Syrkin Wurtele, Joe Chappell, A. Daniel Jones, Mary Dawn Celiz, Nick Ransom, Manhoi Hur, Ludmila Rizshsky, Matthew Crispin, Philip Dixon, Jia Liu, Mark P. Widrlechner, and Basil J. Nikolau

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USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization, Ruohan Xia, Hongge Jia, Junkai Fan, Yajuan Liu, and Jianhang Jia

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Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS, Ruohan Xia, Yajuan Liu, Liuqing Yang, Jozsef Gal, Haining Zhu, and Jianhang Jia

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Krüppel-like Factor 4 Regulates Intestinal Epithelial Cell Morphology and Polarity, Tianxin Yu, Xi Chen, Wen Zhang, Juan Li, Ren Xu, Timothy C Wang, Walden Ai, and Chunming Liu

Submissions from 2011

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An Evolutionarily Conserved Rit GTPase-p38 MAPK Signaling Pathway Mediates Oxidative Stress Resistance, Weikang Cai, Jennifer L. Rudolph, Susan M. W. Harrison, Ling Jin, Aubrey L. Frantz, Douglas A. Harrison, and Douglas A. Andres

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Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened, Yongbin Chen, Noriaki Sasai, Guoqiang Ma, Tao Yue, Jianhang Jia, James Briscoe, and Jin Jiang

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Possible role of death receptor-mediated apoptosis by the E3 ubiquitin ligases Siah2 and POSH, Perry A. Christian, Michael V. Fiandalo, and Steven R. Schwarze

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Laforin, a dual specificity phosphatase involved in Lafora disease, is present mainly as monomeric form with full phosphatase activity, Vikas V. Dukhande, Devin M. Rogers, Carlos Romá-Mateo, Jordi Donderis, Alberto Marina, Adam O. Taylor, Pascual Sanz, and Matthew S. Gentry

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mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways, Pat Gulhati, Kanika A. Bowen, Jianyu Liu, Payton D. Stevens, Piotr G. Rychahou, Min Chen, Eun Y. Lee, Heidi L. Weiss, Kathleen L. O'Connor, Tianyan Gao, and B. Mark Evers

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Activation of β-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters, Junlin Li and Binhua P. Zhou

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Identification of the Allosteric Regulatory Site of Insulysin, Nicholas Noinaj, Sonia K. Bhasin, Eun Suk Song, Kirsten E. Scoggin, Maria A. Juliano, Luiz Juliano, Louis B. Hersh, and David W. Rodgers

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Critical role of PI3K/Akt/GSK3β in motoneuron specification from human neural stem cells in response to FGF2 and EGF, Luis Ojeda, Junling Gao, Kristopher G. Hooten, Enyin Wang, Jason R. Thonhoff, Tiffany J. Dunn, Tianyan Gao, and Ping Wu

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Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19, Liping Ren, Janel R. McLean, Tony R. Hazbun, Stanley Fields, Craig Vander Kooi, Melanie D. Ohi, and Kathleen L. Gould

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Lafora disease E3-ubiquitin ligase malin is related to TRIM32 at both the phylogenetic and functional level, Carlos Romá-Mateo, Daniel Moreno, Santiago Vernia, Teresa Rubio, Travis M. Bridges, Matthew S. Gentry, and Pascual Sanz

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Direct Cloning of Double-Stranded RNAs from RNase Protection Analysis Reveals Processing Patterns of C/D Box SnoRNAs and Provides Evidence for Widespread Antisense Transcript Expression, Manli Shen, Eduardo Eyras, Jie Wu, Amit Khanna, Serene Josiah, Mathieu Rederstorff, Michael Q. Zhang, and Stefan Stamm

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RNA Oxidation Adducts 8-OHG and 8-OHA Change with Aβ42 Levels in Late-Stage Alzheimer's Disease, Adam M. Weidner, Melissa A. Bradley, Tina L. Beckett, Dana M. Niedowicz, Amy L.S. Dowling, Sergey V. Matveev, Harry LeVine, Mark A. Lovell, and M. Paul Murphy