US Patent Number
7892537
Publication Date
2-22-2011
Abstract
Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US)
Application Number
12/767,128
Filing Date
04/26/2010
Recommended Citation
Zhan, Chang-Guo; Zheng, Fang; and Yang, Wenchao, "High Activity Mutants of Butyrylcholinesterase for Cocaine Hydrolysis" (2011). Pharmaceutical Sciences Faculty Patents. 1.
https://uknowledge.uky.edu/ps_patents/1
