Abstract
Oral cancer represents a health burden worldwide with approximate 275,000 new cases diagnosed annually. Its poor prognosis is due to local tumor invasion and frequent lymph node metastasis. Better understanding and development of novel treatments and chemo-preventive approaches for the preventive and therapeutic intervention of this type of cancer are necessary. Recent development of dietary polyphenols as cancer preventives and therapeutic agents is of great interest due to their antioxidant and anti-carcinogenic activities. Polyphenols may inhibit carcinogenesis in the stage of initiation, promotion, or progression. In particular, dietary polyphenols decrease incidence of carcinomas and exert protection against oral cancer by induction of cell death and inhibition of tumor growth, invasion, and metastasis. In this review, we discuss current progress of dietary polyphenols against oral cancers in vitro, in vivo, and at population levels.
Document Type
Article
Publication Date
6-14-2013
Digital Object Identifier (DOI)
http://dx.doi.org/10.3390/nu5062173
Repository Citation
Ding, Yijian; Yao, Hua; Yao, Yanan; Fai, Leonard Yenwong; and Zhang, Zhuo, "Protection of Dietary Polyphenols against Oral Cancer" (2013). Toxicology and Cancer Biology Faculty Publications. 17.
https://uknowledge.uky.edu/toxicology_facpub/17
Notes/Citation Information
Published in Nutrients, v. 5, no. 6, p. 2173-2191.
© 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).