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Abstract

A less invasive paracorporeal single port pulsatile ventricular assist device (sppVAD) was developed for cardiogenic shock. This compact sppVAD includes a valved single lumen cannula (VSLC), valveless single port diaphragm displacement pump (spDDP), and portable console. A 33/27 Fr VSLC was fabricated for mock loop testing, a 28/25 Fr VSLC was made for 6 hours sheep testing (n = 5, 44–52 kg), and valveless spDDP with portable console was made. The sppVAD (33/27 Fr VSLC) achieved 6.2 L/min flow in mock loop. In sheep, the 28/25 Fr VSLC was inserted without cardiopulmonary bypass from apex to ascending aorta within 1 minute after apex exposure. The sppVAD achieved 3.75 L/min flow in sheep with stable hemodynamics. Hemoglobin, free hemoglobin, and platelet/white blood cell counts were unchanged through 6 hours. Thus, our less invasive sppVAD achieved total left ventricle support with acceptable short-term hemocompatibility, showing good promise as a temporary VAD for cardiogenic shock.

Document Type

Article

Publication Date

2026

Notes/Citation Information

2950-1334/© 2026 The Author(s). Published by Elsevier Inc. on behalf of International Society for Heart and Lung Transplantation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Digital Object Identifier (DOI)

https://doi.org/10.1016/j.jhlto.2026.100540

Funding Information

This work was supported by an NIH Phase I SBIR grant (R43HL158430).

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