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Abstract
A 7-day-old male infant born to a healthy 33-year-old female at 37 weeks of gestation was brought to the local emergency department (ED) with sudden-onset tonic-clonic seizures. Laboratory testing revealed extreme hypocalcemia (ionized calcium of 3.2 mg/dl) and undetectable parathyroid hormone (PTH/ml). Concomitant evaluation of the mother revealed both elevated ionized calcium (5.9 mg/dl) and PTH (116 pg/ml). The mother underwent preoperative ultrasound localization and sestamibi scan, followed promptly by parathyroidectomy. Given the cystic appearance and presence of multiglandular disease, evaluation for familial cystic parathyroid adenomatosis (hyperparathyroidism-jaw bone-tumor syndrome) and MEN 1 were undertaken. The infant was stabilized and discharged home. He returned to the ED with seizures at 1 month of age. After increasing calcium supplementation appropriately, he was monitored with weekly office visits. This represents a unique case of undiagnosed maternal primary hyperparathyroidism manifesting with intrauterine parathyroid suppression and hypocalcemic seizures in the newborn.
Document Type
Article
Publication Date
3-25-2015
Digital Object Identifier (DOI)
http://dx.doi.org/10.1093/jscr/rjv031
Repository Citation
Long, Kristin; Cartwright, Tessa; Sloan, David A.; and Lee, Cortney Y., "Cystic Multiglandular Maternal Hyperparathyroidism Diagnosed by Neonatal Hypocalcemic Seizures" (2015). Surgery Faculty Publications. 18.
https://uknowledge.uky.edu/surgery_facpub/18
Figure 1 JPEG: (a) Intraoperative photograph showing cystic parathyroid glands. (b) Cystic parathyroid glands
F1.ppt (195 kB)
Figure 1 Powerpoint: (a) Intraoperative photograph showing cystic parathyroid glands. (b) Cystic parathyroid glands.
Notes/Citation Information
Published in The Journal of Surgical Case Reports, v. 2015, no. 3, p. 1-3.
Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com