Heart Failure in Humans Reduces Contractile Force in Myocardium from Both Ventricles

Authors

Cheavar A. Blair, University of Kentucky
Elizabeth A Brundage, The Ohio State University
Katherine L. Thompson, University of KentuckyFollow
Arnold J. Stromberg, University of KentuckyFollow
Maya Guglin, University of Kentucky
Brandon J Biesiadecki, The Ohio State University
Kenneth S. Campbell, University of KentuckyFollow

Abstract

This study measured how heart failure affects the contractile properties of the human myocardium from the left and right ventricles. The data showed that maximum force and maximum power were reduced by approximately 30% in multicellular preparations from both ventricles, possibly because of ventricular remodeling (e.g., cellular disarray and/or excess fibrosis). Heart failure increased the calcium (Ca²⁺) sensitivity of contraction in both ventricles, but the effect was bigger in right ventricular samples. The changes in Ca²⁺ sensitivity were associated with ventricle-specific changes in the phosphorylation of troponin I, which indicated that adrenergic stimulation might induce different effects in the left and right ventricles.

Document Type

Article

Publication Date

8-2020

Notes/Citation Information

Published in JACC: Basic to Translational Science, v. 5, issue 8.

© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Digital Object Identifier (DOI)

https://doi.org/10.1016/j.jacbts.2020.05.014

Repository Citation

Blair, Cheavar A.; Brundage, Elizabeth A; Thompson, Katherine L.; Stromberg, Arnold J.; Guglin, Maya; Biesiadecki, Brandon J; and Campbell, Kenneth S., "Heart Failure in Humans Reduces Contractile Force in Myocardium from Both Ventricles" (2020). Statistics Faculty Publications. 29.
https://uknowledge.uky.edu/statistics_facpub/29