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Submissions from 2020

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Distinct Clinicopathologic Clusters of Persons with TDP-43 Proteinopathy, Yuriko Katsumata, Erin L. Abner, Shama Karanth, Merilee A. Teylan, Charles N. Mock, Matthew D. Cykowski, Edward B. Lee, Kevin L. Boehme, Shubhabrata Mukherjee, John S. K. Kauwe, Richard J. Kryscio, Frederick A. Schmitt, David W. Fardo, and Peter T. Nelson

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Longitudinal Assessment of Dementia Measures in Down Syndrome, Lisa Mason Koehl, Jordan P. Harp, Kathryn L. Van Pelt, Elizabeth Head, and Frederick A. Schmitt

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The Relationship between Sport-Related Concussion and Sensation-Seeking, Spencer W. Liebel, Kathryn L. Van Pelt, Gian-Gabriel P. Garcia, Lauren L. Czerniak, Michael A. McCrea, Thomas W. McAllister, Steven P. Broglio, and CARE Consortium Investigators

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Optimization and Validation of a Modified Radial-Arm Water Maze Protocol Using a Murine Model of Mild Closed Head Traumatic Brain Injury, Teresa Macheda, Kelly N. Roberts, Josh M. Morganti, David J. Braun, and Adam D. Bachstetter

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Distribution of Microglial Phenotypes as a Function of Age and Alzheimer's Disease Neuropathology in the Brains of People with Down Syndrome, Alessandra C. Martini, Alex M. Helman, Katie L. McCarty, Ira T. Lott, Eric Doran, Frederick A. Schmitt, and Elizabeth Head

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The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia, Marzia Perluigi, Antonella Tramutola, Sara Pagnotta, Eugenio Barone, and D. Allan Butterfield

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Therapeutic Trem2 Activation Ameliorates Amyloid-Beta Deposition and Improves Cognition in the 5XFAD Model of Amyloid Deposition, Brittani R. Price, Tiffany L. Sudduth, Erica M. Weekman, Sherika Johnson, Danielle Hawthorne, Abigail E. Woolums, and Donna M. Wilcock

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Rivastigmine Modifies the α-Secretase Pathway and Potentially Early Alzheimer's Disease, Balmiki Ray, Bryan Maloney, Kumar Sambamurti, Hanuma K. Karnati, Peter T. Nelson, Nigel H. Greig, and Debomoy K. Lahiri

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Limbic-Predominant Age-Related TDP-43 Encephalopathy Differs from Frontotemporal Lobar Degeneration, John L. Robinson, Sílvia Porta, Filip G. Garrett, Panpan Zhang, Sharon X. Xie, EunRan Suh, Vivianna M. Van Deerlin, Erin L. Abner, Gregory A. Jicha, Justin M. Barber, Virginia M-Y Lee, Edward B. Lee, John Q. Trojanowski, and Peter T. Nelson

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Infectious Hypothesis of Alzheimer Disease, Charles E. Seaks and Donna M. Wilcock

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Brain Structure Changes over Time in Normal and Mildly Impaired Aged Persons, Charles D. Smith, Linda J. Van Eldik, Gregory A. Jicha, Frederick A. Schmitt, Peter T. Nelson, Erin L. Abner, Richard J. Kryscio, Richard R. Murphy, and Anders H. Andersen

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First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers, Linda J. Van Eldik, Lumy Sawaki, Karen Bowen, Daniel T. Laskowitz, Robert J. Noveck, Byron Hauser, Lynn Jordan, Tracy G. Spears, Huali Wu, Kevin Watt, Shruti Raja, Saktimayee M. Roy, D. Martin Watterson, and Jeffrey T. Guptill

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Feasibility of Dual-Task Gait to Estimate Alzheimer's Related Cognitive Decline in Down Syndrome, Kathryn L. Van Pelt, Lisa Mason Koehl, Allison M. Caban-Holt, Amelia J. Anderson-Mooney, Elizabeth Head, and Frederick A. Schmitt

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Oral Gavage Delivery of Stable Isotope Tracer for in Vivo Metabolomics, Holden C. Williams, Margaret A. Piron, Grant K. Nation, Adeline E. Walsh, Lyndsay E. A. Young, Ramon C. Sun, and Lance A. Johnson

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Hierarchical Clustering Analyses of Plasma Proteins in Subjects With Cardiovascular Risk Factors Identify Informative Subsets Based on Differential Levels of Angiogenic and Inflammatory Biomarkers, Zachary Winder, Tiffany L. Sudduth, David W. Fardo, Qiang Cheng, Larry B. Goldstein, Peter T. Nelson, Frederick A. Schmitt, Gregory A. Jicha, and Donna M. Wilcock

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Cortical Iron Disrupts Functional Connectivity Networks Supporting Working Memory Performance in Older Adults, Valentinos Zachariou, Christopher E. Bauer, Elayna R. Seago, Flavius D. Raslau, David K. Powell, and Brian T. Gold

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TDP-43 Mediated Blood-Brain Barrier Permeability and Leukocyte Infiltration Promote Neurodegeneration in a Low-Grade Systemic Inflammation Mouse Model, Frank Zamudio, Anjanet R. Loon, Shayna Smeltzer, Khawla Benyamine, Nanda K. Navalpur Shanmugam, Nicholas J. F. Stewart, Daniel C. Lee, Kevin Nash, and Maj-Linda B. Selenica

Submissions from 2019

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Tobacco Smoking and Dementia in a Kentucky Cohort: A Competing Risk Analysis, Erin L. Abner, Peter T. Nelson, Gregory A. Jicha, Gregory E. Cooper, David W. Fardo, Frederick A. Schmitt, and Richard J. Kryscio

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White Matter Hyperintensities in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Knowledge Gaps and Opportunities, Jessica Alber, Suvarna Alladi, Hee-Joon Bae, David A. Barton, Laurel A. Beckett, Joanne M. Bell, Sara E. Berman, Geert Jan Biessels, Sandra E. Black, Isabelle Bos, Gene L. Bowman, Emanuele Brai, Adam M. Brickman, Brandy L. Callahan, Roderick A. Corriveau, Silvia Fossati, Rebecca F. Gottesman, Deborah R. Gustafson, Vladimir Hachinski, Kathleen M. Hayden, Alex M. Helman, Timothy M. Hughes, Jeremy D. Isaacs, Angela L. Jefferson, Sterling C. Johnson, Alifiya Kapasi, Silke Kern, Jay C. Kwon, Juraj Kukolja, Athene Lee, Brittani R. Price, and Donna M. Wilcock

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Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain, Roxana Aldea, Roy O. Weller, Donna M. Wilcock, Roxana O Carare, and Giles Richardson

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White Matter Hyperintensity Regression: Comparison of Brain Atrophy and Cognitive Profiles with Progression and Stable Groups, Omar M. Al-Janabi, Christopher E. Bauer, Larry B. Goldstein, Richard R. Murphy, Ahmed A. Bahrani, Charles D. Smith, Donna M. Wilcock, Brian T. Gold, and Gregory A. Jicha

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Post-Acquisition Processing Confounds in Brain Volumetric Quantification of White Matter Hyperintensities, Ahmed A. Bahrani, Omar M. Al-Janabi, Erin L. Abner, Shoshana H. Bardach, Richard J. Kryscio, Donna M. Wilcock, Charles D. Smith, and Gregory A. Jicha

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Perspectives of African American Older Adults on Brain Health: "Brains Get Tired Too", Shoshana H. Bardach, Beverly Benton, Charlene Walker, Doris Love Alfred, Eseosa T. Ighodaro, Allison M. Caban-Holt, and Gregory A. Jicha

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Distinct Patterns of Default Mode and Executive Control Network Circuitry Contribute to Present and Future Executive Function in Older Adults, Christopher A. Brown, Frederick A. Schmitt, Charles D. Smith, and Brian T. Gold

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Restoration of Aberrant mTOR Signaling by Intranasal Rapamycin Reduces Oxidative Damage: Focus on HNE-Modified Proteins in a Mouse Model of Down Syndrome, Fabio Di Domenico, Antonella Tramutola, Eugenio Barone, Chiara Lanzillotta, Olivia Defever, Andrea Arena, Ilaria Zuliani, Cesira Foppoli, Federica Iavarone, Federica Vincenzoni, Massimo Castagnola, D. Allan Butterfield, and Marzia Perluigi