Archived
This content is available here strictly for research, reference, and/or recordkeeping and as such it may not be fully accessible. If you work or study at University of Kentucky and would like to request an accessible version, please use the SensusAccess Document Converter.
Abstract
Transcription factors that mediate neuronal defenses against diverse stresses were quantified in plasma neural-derived exosomes of Alzheimer's disease or frontotemporal dementia patients and matched controls. Exosomal levels of low-density lipoprotein receptor-related protein 6, heat-shock factor-1, and repressor element 1-silencing transcription factor all were significantly lower in Alzheimer's disease patients than controls (P < 0.0001). In frontotemporal dementia, the only significant difference was higher levels of repressor element 1-silencing transcription factor than in controls. Exosomal transcription factors were diminished 2-10 years before clinical diagnosis of Alzheimer's disease. Low exosomal levels of survival proteins may explain decreased neuronal resistance to Alzheimer's disease neurotoxic proteins.
Document Type
Article
Publication Date
7-2015
Digital Object Identifier (DOI)
http://dx.doi.org/10.1002/acn3.211
Funding Information
Intramural Research Program of the National Institute on Aging (NIA; D. K.), P30 AG028383 (E. L. A.), and an unrestricted grant for method development from Nanosomix, Inc. (E. J. G.).
Repository Citation
Goetzl, Edward J.; Boxer, Adam; Schwartz, Janice B.; Abner, Erin; Petersen, Ronald C.; Miller, Bruce L.; Carlson, Olga D.; Mustapic, Maja; and Kapogiannis, Dimitrios, "Low Neural Exosomal Levels of Cellular Survival Factors in Alzheimer's Disease" (2015). Sanders-Brown Center on Aging Faculty Publications. 60.
https://uknowledge.uky.edu/sbcoa_facpub/60
Figure S1.
acn3211-sup-0002-TableS1.docx (14 kB)
Table S1.
acn3211-sup-0003-TableS2.docx (14 kB)
Table S2.
Notes/Citation Information
Published in Annals of Clinical and Translational Neurology, v. 2, no. 7, p. 769-773.
© 2015 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.