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Abstract
Calcineurin (CN) is a Ca2+/calmodulin-dependent protein phosphatase with high abundance in nervous tissue. Though enriched in neurons, CN can become strongly induced in subsets of activated astrocytes under different pathological conditions where it interacts extensively with the nuclear factor of activated T cells (NFATs). Recent work has shown that regions of small vessel damage are associated with the upregulation of a proteolized, highly active form of CN in nearby astrocytes, suggesting a link between the CN/NFAT pathway and chronic cerebrovascular disease. In this Mini Review article, we discuss CN/NFAT signaling properties in the context of vascular disease and use previous cell type-specific intervention studies in Alzheimer’s disease and traumatic brain injury models as a framework to understand how astrocytic CN/NFATs may couple vascular pathology to neurodegeneration and cognitive loss.
Document Type
Review
Publication Date
9-21-2018
Digital Object Identifier (DOI)
https://doi.org/10.3389/fnagi.2018.00287
Funding Information
This work was supported by National Institutes of Health Grants AG027297, AG056998, AG051945 and a gift from the Hazel Embry Research Trust.
Repository Citation
Kraner, Susan D. and Norris, Christopher M., "Astrocyte Activation and the Calcineurin/NFAT Pathway in Cerebrovascular Disease" (2018). Sanders-Brown Center on Aging Faculty Publications. 114.
https://uknowledge.uky.edu/sbcoa_facpub/114
Included in
Cognitive Neuroscience Commons, Diseases Commons, Geriatrics Commons, Neurology Commons, Neurosciences Commons
Notes/Citation Information
Published in Frontiers in Aging Neuroscience, v. 10, 287, p. 1-7.
© 2018 Kraner and Norris.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.