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Submissions from 2020

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Insufficient Sun Exposure Has Become a Real Public Health Problem, Lars Alfredsson, Bruce K Armstrong, D. Allan Butterfield, Rajiv Chowdhury, Frank R. de Gruijl, Martin Feelisch, Cedric F. Garland, Prue H. Hart, David G. Hoel, Ramune Jacobsen, Pelle G. Lindqvist, David J. Llewellyn, Henning Tiemeier, Richard B. Weller, and Antony R. Young

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Rural Caregivers: Identification of Informational Needs through Telemedicine Questions, Shoshana H. Bardach, Allison Gibson, Kelly Parsons, April Stauffer, and Gregory A. Jicha

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David S. Miller: Scientist, Mentor, Friend--A Tribute and Thank You, Björn Bauer, J. Larry Renfro, Karl J. Karnaky, Rosalinde Masereeuw, Gert Fricker, Ron E. Cannon, and Anika M. S. Hartz

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Microglial-Associated Responses to Comorbid Amyloid Pathology and Hyperhomocysteinemia in an Aged Knock-in Mouse Model of Alzheimer's Disease, David J. Braun, Edgardo R. Dimayuga, Josh M. Morganti, and Linda J. Van Eldik

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Neuroligin-1 Is Altered in the Hippocampus of Alzheimer's Disease Patients and Mouse Models, and Modulates the Toxicity of Amyloid-Beta Oligomers, Julien Dufort-Gervais, Chloé Provost, Laurence Charbonneau, Christopher M. Norris, Frédéric Calon, Valérie Mongrain, and Jonathan Brouillette

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β-Amyloid and Tau Drive Early Alzheimer's Disease Decline While Glucose Hypometabolism Drives Late Decline, Tyler C. Hammond, Xin Xing, Chris Wang, David Ma, Kwangsik Nho, Paul K. Crane, Fanny Elahi, David A. Ziegler, Gongbo Liang, Qiang Cheng, Lucille M. Yanckello, Nathan Jacobs, and Ai-Ling Lin

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Cardiorespiratory Fitness Diminishes the Effects of Age on White Matter Hyperintensity Volume, Nathan F. Johnson, Ahmed A. Bahrani, David K. Powell, Gregory A. Jicha, and Brian T. Gold

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Optimization and Validation of a Modified Radial-Arm Water Maze Protocol Using a Murine Model of Mild Closed Head Traumatic Brain Injury, Teresa Macheda, Kelly N. Roberts, Josh M. Morganti, David J. Braun, and Adam D. Bachstetter

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The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia, Marzia Perluigi, Antonella Tramutola, Sara Pagnotta, Eugenio Barone, and D. Allan Butterfield

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Therapeutic Trem2 Activation Ameliorates Amyloid-Beta Deposition and Improves Cognition in the 5XFAD Model of Amyloid Deposition, Brittani R. Price, Tiffany L. Sudduth, Erica M. Weekman, Sherika Johnson, Danielle Hawthorne, Abigail E. Woolums, and Donna M. Wilcock

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Limbic-Predominant Age-Related TDP-43 Encephalopathy Differs from Frontotemporal Lobar Degeneration, John L. Robinson, Sílvia Porta, Filip G. Garrett, Panpan Zhang, Sharon X. Xie, EunRan Suh, Vivianna M. Van Deerlin, Erin L. Abner, Gregory A. Jicha, Justin M. Barber, Virginia M-Y Lee, Edward B. Lee, John Q. Trojanowski, and Peter T. Nelson

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First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers, Linda J. Van Eldik, Lumy Sawaki, Karen Bowen, Daniel T. Laskowitz, Robert J. Noveck, Byron Hauser, Lynn Jordan, Tracy G. Spears, Huali Wu, Kevin Watt, Shruti Raja, Saktimayee M. Roy, D. Martin Watterson, and Jeffrey T. Guptill

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Hierarchical Clustering Analyses of Plasma Proteins in Subjects With Cardiovascular Risk Factors Identify Informative Subsets Based on Differential Levels of Angiogenic and Inflammatory Biomarkers, Zachary Winder, Tiffany L. Sudduth, David W. Fardo, Qiang Cheng, Larry B. Goldstein, Peter T. Nelson, Frederick A. Schmitt, Gregory A. Jicha, and Donna M. Wilcock

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Cortical Iron Disrupts Functional Connectivity Networks Supporting Working Memory Performance in Older Adults, Valentinos Zachariou, Christopher E. Bauer, Elayna R. Seago, Flavius D. Raslau, David K. Powell, and Brian T. Gold

Submissions from 2019

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Tobacco Smoking and Dementia in a Kentucky Cohort: A Competing Risk Analysis, Erin L. Abner, Peter T. Nelson, Gregory A. Jicha, Gregory E. Cooper, David W. Fardo, Frederick A. Schmitt, and Richard J. Kryscio

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White Matter Hyperintensities in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Knowledge Gaps and Opportunities, Jessica Alber, Suvarna Alladi, Hee-Joon Bae, David A. Barton, Laurel A. Beckett, Joanne M. Bell, Sara E. Berman, Geert Jan Biessels, Sandra E. Black, Isabelle Bos, Gene L. Bowman, Emanuele Brai, Adam M. Brickman, Brandy L. Callahan, Roderick A. Corriveau, Silvia Fossati, Rebecca F. Gottesman, Deborah R. Gustafson, Vladimir Hachinski, Kathleen M. Hayden, Alex M. Helman, Timothy M. Hughes, Jeremy D. Isaacs, Angela L. Jefferson, Sterling C. Johnson, Alifiya Kapasi, Silke Kern, Jay C. Kwon, Juraj Kukolja, Athene Lee, Brittani R. Price, and Donna M. Wilcock

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Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain, Roxana Aldea, Roy O. Weller, Donna M. Wilcock, Roxana O Carare, and Giles Richardson

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Restoration of Aberrant mTOR Signaling by Intranasal Rapamycin Reduces Oxidative Damage: Focus on HNE-Modified Proteins in a Mouse Model of Down Syndrome, Fabio Di Domenico, Antonella Tramutola, Eugenio Barone, Chiara Lanzillotta, Olivia Defever, Andrea Arena, Ilaria Zuliani, Cesira Foppoli, Federica Iavarone, Federica Vincenzoni, Massimo Castagnola, D. Allan Butterfield, and Marzia Perluigi

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Evaluating Trajectories of Episodic Memory in Normal Cognition and Mild Cognitive Impairment: Results from ADNI, Xiuhua Ding, Richard J. Charnigo, Frederick A. Schmitt, Richard J. Kryscio, Erin L. Abner, and Alzheimer’s Disease Neuroimaging Initiative

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The Inflammatory Response After Ischemic Stroke: Targeting β2 and β1 Integrins, Danielle N. Edwards and Gregory J. Bix

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Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation, Brandon C. Farmer, Jude Kluemper, and Lance A. Johnson

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Non-Fasting High-Density Lipoprotein Is Associated With White Matter Microstructure in Healthy Older Adults, Nathan F. Johnson, Brian T. Gold, Dorothy Ross, Alison L. Bailey, Jody L. Clasey, Vedant Gupta, Steve W. Leung, and David K. Powell

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Absence of Endothelial α5β1 Integrin Triggers Early Onset of Experimental Autoimmune Encephalomyelitis Due to Reduced Vascular Remodeling and Compromised Vascular Integrity, Ravi Kant, Sebok K. Halder, Gregory J. Bix, and Richard Milner

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Deletion of p38α MAPK in Microglia Blunts Trauma-Induced Inflammatory Responses in Mice, Josh M. Morganti, Danielle S. Goulding, and Linda J. Van Eldik

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Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE): Consensus Working Group Report, Peter T. Nelson, Dennis W. Dickson, John Q. Trojanowski, Clifford R. Jack, Patricia A. Boyle, Konstantinos Arfanakis, Rosa Rademakers, Irina Alafuzoff, Johannes Attems, Carol Brayne, Ian T. S. Coyle-Gilchrist, Helena C. Chui, David W. Fardo, Margaret E. Flanagan, Glenda Halliday, Suvi R. K. Hokkanen, Sally Hunter, Gregory A. Jicha, Yuriko Katsumata, Claudia H. Kawas, C. Dirk Keene, Gabor G. Kovacs, Walter A. Kukull, Allan I. Levey, Nazanin Makkinejad, Thomas J. Montine, Shigeo Murayama, Melissa E. Murray, Sukriti Nag, Robert A. Rissman, William W. Seeley, Reisa A. Sperling, Charles L. White III, Lei Yu, and Julie A. Schneider