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Submissions from 2021

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New Evidence for P-gp-Mediated Export of Amyloid-β PEPTIDES in Molecular, Blood-Brain Barrier and Neuronal Models, Amanda B. Chai, Anika M. S. Hartz, Xuexin Gao, Alryel Yang, Richard Callaghan, and Ingrid C. Gelissen

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Arginase 1 Insufficiency Precipitates Amyloid-β Deposition and Hastens Behavioral Impairment in a Mouse Model of Amyloidosis, Chao Ma, Jerry B. Hunt, Maj-Linda B. Selenica, Awa Sanneh, Leslie A. Sandusky-Beltran, Mallory Watler, Rana Daas, Andrii Kovalenko, Huimin Liang, Devon Placides, Chuanhai Cao, Xiaoyang Lin, Michael B. Orr, Bei Zhang, John C. Gensel, David J. Feola, Marcia N. Gordon, Dave Morgan, Paula C. Bickford, and Daniel C. Lee

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Temporal Changes in Inflammatory Mitochondria-Enriched MicroRNAs Following Traumatic Brain Injury and Effects of miR-146a Nanoparticle Delivery, Wang-Xia Wang, Pareshkumar Prajapati, Hemendra J. Vekaria, Malinda Spry, Amber L. Cloud, Patrick G. Sullivan, and Joe E. Springer

Submissions from 2020

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Insufficient Sun Exposure Has Become a Real Public Health Problem, Lars Alfredsson, Bruce K Armstrong, D. Allan Butterfield, Rajiv Chowdhury, Frank R. de Gruijl, Martin Feelisch, Cedric F. Garland, Prue H. Hart, David G. Hoel, Ramune Jacobsen, Pelle G. Lindqvist, David J. Llewellyn, Henning Tiemeier, Richard B. Weller, and Antony R. Young

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Will "Social Distancing" Lead to Future "Research Distancing": A Reflection on COVID-19 Impacts on Alzheimer's Disease Research, Shoshana H. Bardach, Allison K. Gibson, Elizabeth K. Rhodus, and Gregory A. Jicha

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Rural Caregivers: Identification of Informational Needs through Telemedicine Questions, Shoshana H. Bardach, Allison Gibson, Kelly Parsons, April Stauffer, and Gregory A. Jicha

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David S. Miller: Scientist, Mentor, Friend--A Tribute and Thank You, Björn Bauer, J. Larry Renfro, Karl J. Karnaky, Rosalinde Masereeuw, Gert Fricker, Ron E. Cannon, and Anika M. S. Hartz

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Microglial-Associated Responses to Comorbid Amyloid Pathology and Hyperhomocysteinemia in an Aged Knock-in Mouse Model of Alzheimer's Disease, David J. Braun, Edgardo R. Dimayuga, Josh M. Morganti, and Linda J. Van Eldik

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Neuroligin-1 Is Altered in the Hippocampus of Alzheimer's Disease Patients and Mouse Models, and Modulates the Toxicity of Amyloid-Beta Oligomers, Julien Dufort-Gervais, Chloé Provost, Laurence Charbonneau, Christopher M. Norris, Frédéric Calon, Valérie Mongrain, and Jonathan Brouillette

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β-Amyloid and Tau Drive Early Alzheimer's Disease Decline While Glucose Hypometabolism Drives Late Decline, Tyler C. Hammond, Xin Xing, Chris Wang, David Ma, Kwangsik Nho, Paul K. Crane, Fanny Elahi, David A. Ziegler, Gongbo Liang, Qiang Cheng, Lucille M. Yanckello, Nathan Jacobs, and Ai-Ling Lin

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Cardiorespiratory Fitness Diminishes the Effects of Age on White Matter Hyperintensity Volume, Nathan F. Johnson, Ahmed A. Bahrani, David K. Powell, Gregory A. Jicha, and Brian T. Gold

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Distinct Clinicopathologic Clusters of Persons with TDP-43 Proteinopathy, Yuriko Katsumata, Erin L. Abner, Shama Karanth, Merilee A. Teylan, Charles N. Mock, Matthew D. Cykowski, Edward B. Lee, Kevin L. Boehme, Shubhabrata Mukherjee, John S. K. Kauwe, Richard J. Kryscio, Frederick A. Schmitt, David W. Fardo, and Peter T. Nelson

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Longitudinal Assessment of Dementia Measures in Down Syndrome, Lisa Mason Koehl, Jordan P. Harp, Kathryn L. Van Pelt, Elizabeth Head, and Frederick A. Schmitt

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The Relationship between Sport-Related Concussion and Sensation-Seeking, Spencer W. Liebel, Kathryn L. Van Pelt, Gian-Gabriel P. Garcia, Lauren L. Czerniak, Michael A. McCrea, Thomas W. McAllister, Steven P. Broglio, and CARE Consortium Investigators

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Optimization and Validation of a Modified Radial-Arm Water Maze Protocol Using a Murine Model of Mild Closed Head Traumatic Brain Injury, Teresa Macheda, Kelly N. Roberts, Josh M. Morganti, David J. Braun, and Adam D. Bachstetter

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Distribution of Microglial Phenotypes as a Function of Age and Alzheimer's Disease Neuropathology in the Brains of People with Down Syndrome, Alessandra C. Martini, Alex M. Helman, Katie L. McCarty, Ira T. Lott, Eric Doran, Frederick A. Schmitt, and Elizabeth Head

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The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia, Marzia Perluigi, Antonella Tramutola, Sara Pagnotta, Eugenio Barone, and D. Allan Butterfield

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Therapeutic Trem2 Activation Ameliorates Amyloid-Beta Deposition and Improves Cognition in the 5XFAD Model of Amyloid Deposition, Brittani R. Price, Tiffany L. Sudduth, Erica M. Weekman, Sherika Johnson, Danielle Hawthorne, Abigail E. Woolums, and Donna M. Wilcock

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Limbic-Predominant Age-Related TDP-43 Encephalopathy Differs from Frontotemporal Lobar Degeneration, John L. Robinson, Sílvia Porta, Filip G. Garrett, Panpan Zhang, Sharon X. Xie, EunRan Suh, Vivianna M. Van Deerlin, Erin L. Abner, Gregory A. Jicha, Justin M. Barber, Virginia M-Y Lee, Edward B. Lee, John Q. Trojanowski, and Peter T. Nelson

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Infectious Hypothesis of Alzheimer Disease, Charles E. Seaks and Donna M. Wilcock

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Brain Structure Changes over Time in Normal and Mildly Impaired Aged Persons, Charles D. Smith, Linda J. Van Eldik, Gregory A. Jicha, Frederick A. Schmitt, Peter T. Nelson, Erin L. Abner, Richard J. Kryscio, Richard R. Murphy, and Anders H. Andersen

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First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers, Linda J. Van Eldik, Lumy Sawaki, Karen Bowen, Daniel T. Laskowitz, Robert J. Noveck, Byron Hauser, Lynn Jordan, Tracy G. Spears, Huali Wu, Kevin Watt, Shruti Raja, Saktimayee M. Roy, D. Martin Watterson, and Jeffrey T. Guptill

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Feasibility of Dual-Task Gait to Estimate Alzheimer's Related Cognitive Decline in Down Syndrome, Kathryn L. Van Pelt, Lisa Mason Koehl, Allison M. Caban-Holt, Amelia J. Anderson-Mooney, Elizabeth Head, and Frederick A. Schmitt

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Oral Gavage Delivery of Stable Isotope Tracer for in Vivo Metabolomics, Holden C. Williams, Margaret A. Piron, Grant K. Nation, Adeline E. Walsh, Lyndsay E. A. Young, Ramon C. Sun, and Lance A. Johnson

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Hierarchical Clustering Analyses of Plasma Proteins in Subjects With Cardiovascular Risk Factors Identify Informative Subsets Based on Differential Levels of Angiogenic and Inflammatory Biomarkers, Zachary Winder, Tiffany L. Sudduth, David W. Fardo, Qiang Cheng, Larry B. Goldstein, Peter T. Nelson, Frederick A. Schmitt, Gregory A. Jicha, and Donna M. Wilcock