It is unknown whether first-generation electronic cigarettes reduce smoking urges and withdrawal symptoms following a 24 h deprivation period. This study tested whether a first-generation electronic cigarette reduces smoking urges and withdrawal symptoms in cigarette smokers. Following 24 h of tobacco deprivation, using a within-subjects design, eight nontreatment seeking tobacco cigarette smokers (3 females) administered 10 puffs from a conventional cigarette or a first-generation electronic cigarette containing liquid with 0, 8 or 16 mg/ml nicotine. Conventional cigarettes ameliorated smoking urges and electronic cigarettes did not, regardless of nicotine concentration. First-generation electronic cigarettes may not effectively substitute for conventional cigarettes in reducing smoking urges, regardless of nicotine concentration.
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This study was supported by UL1TR000117 awarded to Dr. Kelly by the University of Kentucky Center for Clinical and Translational Science, Lexington, Kentucky.
Harvanko, Arit M.; Martin, Catherine A.; Kryscio, Richard J.; Stoops, William W.; Lile, Joshua A.; and Kelly, Thomas H., "A Prototypical First-Generation Electronic Cigarette Does Not Reduce Reports of Tobacco Urges or Withdrawal Symptoms Among Cigarette Smokers" (2017). Psychology Faculty Publications. 142.