US Patent Number
The present invention is directed to novel codrugs comprising bupropion or hydroxybupropion and an opioid antagonist or an opioid agonist joined together by chemical bonding. The codrugs provide a significant increase in the transdermal flux across human skin, as compared to the basic opioid antagonist or opioid agonist.
University of Kentucky Research Foundation, Lexington, KY (US)
Stinchcomb, Audra L.; Crooks, Peter A.; Hamad, Mohamad O.; and Kiptoo, Paul K., "Enhancing Transdermal Delivery of Opioid Antagonists and Agonists Using Codrugs Linked To Bupropion or Hydroxybupropion" (2014). Pharmaceutical Sciences Faculty Patents. 27.