US Patent Number
8653271
Publication Date
2-18-2014
Abstract
The present invention is directed to novel codrugs comprising bupropion or hydroxybupropion and an opioid antagonist or an opioid agonist joined together by chemical bonding. The codrugs provide a significant increase in the transdermal flux across human skin, as compared to the basic opioid antagonist or opioid agonist.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US)
Application Number
11/907,954
Filing Date
10/18/2007
Recommended Citation
Stinchcomb, Audra L.; Crooks, Peter A.; Hamad, Mohamad O.; and Kiptoo, Paul K., "Enhancing Transdermal Delivery of Opioid Antagonists and Agonists Using Codrugs Linked To Bupropion or Hydroxybupropion" (2014). Pharmaceutical Sciences Faculty Patents. 27.
https://uknowledge.uky.edu/ps_patents/27
