Methods for Diagnosing and Treating Alzheimer's Disease (AD) Using the Molecules that Stabilize Intracellular Calcium (CA₂₊) Release

Authors

Philip W. Landfield, University of KentuckyFollow
John C. Gant, University of KentuckyFollow
Eric M. Blalock, University of KentuckyFollow
Kuey-Chu Chen, University of KentuckyFollow
Olivier Thibault, University of KentuckyFollow
Nada M. Porter, University of KentuckyFollow

US Patent Number

9464322

Publication Date

10-11-2016

Abstract

The subject technology relates, in part, to a method of treating Alzheimer's Disease (AD), early-stage AD, elevated risk of AD, mild cognitive impairment (MCI), or other forms of age-related cognitive decline in a subject in need thereof by administering to the subject a molecule that promotes calcium-release stabilization in ryanodine receptors (RyRs) and/or inosital triphosphate receptors (InsP3Rs) in brain cells. Diagnostic methods using calcium-release stabilizing immunophilins, junctophilins or calmodulin are also disclosed.

Assignees

University of Kentucky Research Foundation, Lexington, KY (US)

Application Number

13/608,596

Filing Date

09/10/2012

Recommended Citation

Landfield, Philip W.; Gant, John C.; Blalock, Eric M.; Chen, Kuey-Chu; Thibault, Olivier; and Porter, Nada M., "Methods for Diagnosing and Treating Alzheimer's Disease (AD) Using the Molecules that Stabilize Intracellular Calcium (CA₂₊) Release" (2016). Pharmacology and Nutritional Sciences Faculty Patents. 50.
https://uknowledge.uky.edu/pharmacol_patents/50