US Patent Number
7739056
Publication Date
6-15-2010
Abstract
A statistical and functional correlation strategy to identify changes in cellular pathways specifically linked to impaired cognitive function with aging. Analyses using the strategy identified multiple groups of genes expressed in the hippocampi of mammals, where the genes were expressed at different levels for several ages. The aging changes in expression began before mid-life. Many of the genes were involved in specific neuronal and glial pathways with previously unrecognized relationships to aging and/or cognitive decline. These identified genes and the proteins they encode can be used as novel biomarkers of brain aging and as targets for developing treatment methods against age-related cognitive decline, Alzheimer's Disease and Parkinson's Disease.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US)
Application Number
12/379,520
Filing Date
02/24/2009
Recommended Citation
Landfield, Philip W.; Blalock, Eric M.; Chen, Kuey-Chu; and Foster, Thomas S., "Biomarkers for Aging" (2010). Pharmacology and Nutritional Sciences Faculty Patents. 43.
https://uknowledge.uky.edu/pharmacol_patents/43
