Abstract
Over the past 15 years, insights into sterol metabolism have improved our understanding of the relationship between lipids and common conditions such as atherosclerosis and Alzheimer's Disease (AD). A better understanding of sterol lipid metabolism in individuals with Down Syndrome (DS) may help elucidate how this population's unique metabolic characteristics influence their risks for atherosclerosis and AD. To revisit the question of whether sterol lipid parameters may be altered in DS subjects, we performed a pilot study to assess traditional serum sterol lipids and lipoproteins, as well as markers of sterol biosynthesis, metabolites, and plant sterols in 20 subjects with DS compared to age-matched controls. Here we report that the levels of nearly all lipids and lipoproteins examined are similar to control subjects, suggesting that trisomy 21 does not lead to pronounced general alterations in sterol lipid metabolism. However, the levels of serum brassicasterol were markedly reduced in DS subjects.
Document Type
Article
Publication Date
2012
Digital Object Identifier (DOI)
http://dx.doi.org/10.1155/2012/179318
Repository Citation
Tansley, Gavin; Holmes, Daniel T.; Lütjohann, Dieter; Head, Elizabeth; and Wellington, Cheryl L., "Sterol Lipid Metabolism in Down Syndrome Revisited: Down Syndrome is Associated with a Selective Reduction in Serum Brassicasterol Levels" (2012). Pharmacology and Nutritional Sciences Faculty Publications. 23.
https://uknowledge.uky.edu/pharmacol_facpub/23
Included in
Medical Nutrition Commons, Medical Pharmacology Commons, Pharmacology, Toxicology and Environmental Health Commons
Notes/Citation Information
Published in Current Gerontology and Geriatrics Research, v. 2012, article ID 179318, p. 1-11.
Copyright © 2012 Gavin Tansley et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.