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Author ORCID Identifier
Date Available
10-17-2018
Year of Publication
2018
Document Type
Doctoral Dissertation
Degree Name
Doctor of Philosophy (PhD)
College
Medicine
Department/School/Program
Pharmacology and Nutritional Sciences
Faculty
Dr. Ai-Ling Lin
Faculty
Dr. Howard Glauert
Faculty
Dr. Ming Gong
Abstract
Alzheimer’s disease (AD) is the most common form of dementia and a growing disease burden that has seen pharmacological interventions primarily fail. Instead, it has been suggested that preventative measures such as a healthy diet may be the best way in preventing AD. Prebiotics are one such potential measure and are fermented into metabolites by the gut microbiota and acting as gut-brain axis components, beneficially impact the brain. However, the impact of prebiotics in AD prevention is unknown. Here we show that the prebiotic inulin increased multiple gut-brain axis components such as scyllo-inositol and short chain fatty acids in the gut, periphery, and in the case of scyllo-inositol, the brain. We found in E3FAD and E4FAD mice fed either a prebiotic or control diet for 4-months, that the consumption of the prebiotic inulin can beneficially alter the gut microbiota, modulate metabolic function, and dramatically increase scyllo-inositol in the brain. This suggests that the consumption of prebiotics can beneficially impact the brain by enhancing metabolism, helping to decrease AD risk factors.
Digital Object Identifier (DOI)
https://doi.org/10.13023/etd.2018.405
Funding Information
This research was supported by the following National Institute of Health and National Institute of Aging grants: NIH T32DK007778, NIH/NIA R01AG054459, NIA K01AG040164, and UL1TR0000117.
Recommended Citation
Hoffman, Jared D., "THE PREBIOTIC INULIN BENEFICIALLY MODULATES THE GUT-BRAIN AXIS BY ENHANCING METABOLISM IN AN APOE4 MOUSE MODEL" (2018). Theses and Dissertations--Pharmacology and Nutritional Sciences. 24.
https://uknowledge.uky.edu/pharmacol_etds/24
Included in
Biochemical Phenomena, Metabolism, and Nutrition Commons, Neuroscience and Neurobiology Commons, Nutrition Commons
