US Patent Number
Polypeptides, compositions, and methods for treating shock are described. A isolated polypeptide, Deltorphin-E, can be administered without concomitant fluid resuscitation, before, concurrently with, or after the onset of shock or the occurrence of an event that creates a risk of shock. Deltorphin-E can be administered in accordance with the method as part of a preconditioning strategy, which reduces the extent of ischemic injury. Deltorphin-E can be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.
University of Kentucky Research Foundation, Lexington, KY (US)
Oeltgen, Peter R. and Govindaswami, Meera, "Compositions and Methods Useful for Treating Circulatory and Hypovolemic Shock" (2010). Pathology and Laboratory Medicine Faculty Patents. 1.