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US Patent Number
5681964
Publication Date
10-28-1997
Abstract
Prodrugs containing an active drug molecule linked to a polyethylene glycol group, and a method of use thereof are described. Exemplary soluble ester prodrugs contain naproxen, triamcinolone acetonide, gancyclovir, taxol, cyclosporin, dideoxyinosine, trihydroxy steroids, and flurbiprofen molecules linked to polyethylene glycol (PEG) groups. Pharmaceutical compositions containing these prodrugs, and a method of using these esters for treating disease states or symptoms are also described.
Assignees
University of Kentucky Research Foundation, Lexington, Ky.
Application Number
318,160
Filing Date
10/05/1994
Recommended Citation
Ashton, Paul; Smith, Thomas J.; Glavinos, Peter G.; Conklin, John D.; Crooks, Peter A.; Riggs, Robert M.; Cynkowski, Tadeusz; and Cynkowska, Grazyna, "Permeable, Non-irritating Prodrugs of Nonsteroidal and Steroidal Agents" (1997). Ophthalmology and Visual Science Faculty Patents. 17.
https://uknowledge.uky.edu/ophthalmology_patents/17
