US Patent Number
A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.
ZymoGenetics, Inc., Seattle, WA (US), University of Kentucky Research Foundation, Lexington, KY (US)
Oeltgen, Peter R.; Bishop, Paul D.; McClain, Craig J.; and Barve, Shirish, "Method for Treating Cytokine Mediated Hepatic Injury" (2005). Graduate Center for Nutritional Sciences Faculty Patents. 25.