US Patent Number

6875742

Publication Date

4-5-2005

Abstract

A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.

Assignees

ZymoGenetics, Inc., Seattle, WA (US), University of Kentucky Research Foundation, Lexington, KY (US)

Application Number

09/971,902

Filing Date

10/05/2001

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