US Patent Number
6716635
Publication Date
4-6-2004
Abstract
The invention relates to methods for identifying compounds which affect cellular stress. In particular, the method relates to identifying compounds which inhibit protein advanced glycation end product formation, where the compounds are carbonyl scavengers which inhibit the formation. The assay involves combing the substance of interest with histone H1 and ADP-ribose, and then measuring fluorescence and protein cross linking. Various inhibitors of protein AGE glycation have been identified, using this assay.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US)
Application Number
09/836,576
Filing Date
04/16/2001
Recommended Citation
Jacobson, Elaine L.; Jacobson, Myron; and Wondrak, Georg T., "Method for Identifying Regulators of Protein-Advanced Glycation End Product (Protein-Age) Formation" (2004). Graduate Center for Nutritional Sciences Faculty Patents. 16.
https://uknowledge.uky.edu/nutrisci_patents/16
