US Patent Number
6403619
Publication Date
6-11-2002
Abstract
The invention relates to the manipulation of enzymatic pathways, such as poly (ADP-ribose) polymerase pathways, which are dependent upon NAD as a substrate. By administering pro-NAD compounds, cell death caused by necrosis and/or apoptosis can be reduced. Further, by inhibiting one or more of these enzymes, the process of cell death can be accelerated, in conditions such as cancer, where acceleration of cellular necrosis and/or apoptosis is desired. Various inhibitors are described.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US)
Application Number
09/549,691
Filing Date
04/14/2000
Recommended Citation
Jacobson, Elaine L. and Jacobson, Myron, "Method for Controlling Cell Necrosis or Apoptosis" (2002). Graduate Center for Nutritional Sciences Faculty Patents. 12.
https://uknowledge.uky.edu/nutrisci_patents/12
