INTRODUCTION: Little is known about how early (eg, commencing antenatally or in the first 12 months after birth) obesity prevention interventions seek to change behaviour and which components are or are not effective. This study aims to (1) characterise early obesity prevention interventions in terms of target behaviours, delivery features and behaviour change techniques (BCTs), (2) explore similarities and differences in BCTs used to target behaviours and (3) explore effectiveness of intervention components in preventing childhood obesity.

METHODS AND ANALYSIS: Annual comprehensive systematic searches will be performed in Epub Ahead of Print/MEDLINE, Embase, Cochrane (CENTRAL), CINAHL, PsycINFO, as well as clinical trial registries. Eligible randomised controlled trials of behavioural interventions to prevent childhood obesity commencing antenatally or in the first year after birth will be invited to join the Transforming Obesity in CHILDren Collaboration. Standard ontologies will be used to code target behaviours, delivery features and BCTs in both published and unpublished intervention materials provided by trialists. Narrative syntheses will be performed to summarise intervention components and compare applied BCTs by types of target behaviours. Exploratory analyses will be undertaken to assess effectiveness of intervention components.

ETHICS AND DISSEMINATION: The study has been approved by The University of Sydney Human Research Ethics Committee (project no. 2020/273) and Flinders University Social and Behavioural Research Ethics Committee (project no. HREC CIA2133-1). The study's findings will be disseminated through peer-reviewed publications, conference presentations and targeted communication with key stakeholders.


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Published in BMJ Open, v. 12, issue 1, 048165.

© Author(s) (or their employer(s)) 2022

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The first 20 authors and the author from the University of Kentucky are shown on the author list above. Please refer to the downloaded document for the complete author list.

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This work was supported by the Australian National Health and Medical Research Council (NHMRC) Ideas Grant TOPCHILD (Transforming Obesity Prevention for CHILDren): Looking into the black box of interventions (GNT1186363). AT reports funding from NIH R01HD073237; AML reports funding from NIH National Center for Advancing Translational Science through grant # UL1TR000117 and UL1TR001998; BJT reports funding from Health Research Council of New Zealand; CGA reports funding from The PepsiCo Foundation; CP reports funding from National Institutes of Health, Robert Wood Johnson Foundation, WHO, US Department of Agriculture; CS reports funding from University of Cincinnati University Research Council; DAOC is supported by an Australian National Health and Medical Research Council (NHMRC) Translating Research into Practice Fellowship (APP1168749); EO reports the PROBIT study was supported by grant MOP-53155 from the Canadian Institutes of Health Research and grant R01 HD050758 from the US National Institutes of Health; IMP reports funding from grant R01DK088244 from the United States National Institute of Diabetes and Digestive and Kidney Diseases; JB reports funding from US Department of Agriculture; JL and LTK reports funding from Fonds NutsOhra awarded (100.939); JS reports funding from NIH NIDDK, NIH NHLBI, PCORI; JLT is an employee of USDA ARS and the Agency did fund the Delta Healthy Sprouts Trial (Project 6401-5300-003-00D); KdlH reports funding from 1R01HD092483-01 (MPI: de la Haye, Salvy), NIH/NICHD; KDH is supported by an Australian Research Council Future Fellowship (FT130100637); LMW reports funding from NHMRC (#393112; #1003780; #1169823); LWo is supported by a NHMRC Career Development and NHF Future Leader Fellowship; MB reports HAPPY was funded by a UK NIHR Programme Grant for Applied Research (project number RP-PG-0407-10044); MR reports The Baby Act Trial was sponsored by the Center for Collaborative Research in Health Disparities under grant U54 MD007600 of the National Institute on Minority Health and Health Disparities from the National Institutes of Health; MJM reports funding from USDA AFRI 2011-68001-30207; NCØ reports their original study was partly funded by the Norwegian Women's Public Health Association, who had no influence on any part of the study design, implementation and evaluation; RG is a Chief Investigator on the Early Prevention of Obesity in Childhood, NHMRC Centre for Research Excellence (1101675); RSG is supported by the National Institute of Food and Agriculture/US Department of Agriculture, award number 2011-68001-30207, and the National Institutes of Health/National Institute of Child Health and Human Development through a K23 Mentored Patient-Oriented Research Career Development Award (K23HD081077; principal investigator: Rachel S. Gross); RL reports funding from UK NPRI (National Prevention Research Initiative), MRC PHIND (Public Health Intervention Development programme); SO'R reports funding from European Unions Horizon 2020 Research and Innovation Programme (Grant Agreement no. 847984) and Australia National Health and Medical Research Council (NHMRC) (Grant application no. APP1194234); S-JS reports funding from NIMHD U54MD000502 (MPI: Salvy & Dutton Project #2), NICHD R01HD092483 (MPI: Salvy & de la Haye); SA-F is a co-investigator on the current INSIGHT grant which follows participants to ages 6 and 9: NIH 2R01DK088244; AP-E reports the SPOON program in Guatemala is funded by the Inter-American Development Bank with donations of The Government of Japan and The PepsiCo Foundation.