US Patent Number
6355244
Publication Date
3-12-2002
Abstract
This invention provides methods of treating psoriasis which entail eliciting an immune response in an individual against an antigen aberrantly expressed in psoriatic tissue, such as a ganglioside, in an individual. The anti-ganglioside immune response is elicited by administration of an antigen such as a ganglioside, an anti-idiotype moiety for a ganglioside, or a polynucleotide encoding an anti-idiotype moiety. Also described is a strategy for developing additional compositions for psoriasis. The compositions elicit an immunological response against a target antigen present on psoriatic tissue, which in turn can be detected using antibody affinity-purified from the serum of the treated subject. The presence of the immunological response correlates positively with control or resolution of the psoriatic symptoms.
Assignees
University of Kentucky Research Foundation, Lexington, KY (US)
Application Number
09/192,838
Filing Date
11/16/1998
Recommended Citation
Foon, Kenneth A. and Chatterjee, Malaya, "Methods and Compositions for the Treatment of Psoriasis" (2002). Microbiology, Immunology and Molecular Genetics Faculty Patents. 6.
https://uknowledge.uky.edu/microbio_patents/6
