Abstract
In this review, we trace the concept and potential functional role of regulatory idiotypes in the immune response to human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus, and hepatitis C virus (HCV). A major idiotype involved in these viral infections is recognized and defined by a murine monoclonal antibody (1F7). Antibodies expressing the idiotype defined by 1F7 are dominant in HIV-1 infection and are also found on many broadly neutralizing antibodies against HIV-1. This regulatory idiotypic axis offers opportunities for exploitation in vaccine development for HIV-1, HCV, and other chronic viral infections.
Document Type
Review
Publication Date
2-5-2016
Digital Object Identifier (DOI)
https://doi.org/10.3389/fonc.2016.00011
Funding Information
MP is supported by a postdoctoral fellowship from the Canadian Institutes of Health Research (CIHR).
Repository Citation
Muller, Sybille; Parsons, Matthew S.; Kohler, Heinz; and Grant, Michael, "The Significance of a Common Idiotype (1F7) on Antibodies Against Human Immune Deficiency Virus Type 1 and Hepatitis C Virus" (2016). Microbiology, Immunology, and Molecular Genetics Faculty Publications. 89.
https://uknowledge.uky.edu/microbio_facpub/89
Included in
Medical Immunology Commons, Medical Microbiology Commons, Molecular Genetics Commons, Oncology Commons
Notes/Citation Information
Published in Frontiers in Oncology, v. 6, article 11, p. 1-7.
Copyright: © 2016 Muller, Parsons, Kohler and Grant.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.