Abstract
The homophilic potential emerges as an important biological principle to boost the potency of immunoglobulins. Since homophilic antibodies in human and mouse sera exist prior environmental exposure, they are part of the natural antibody repertoire. Nevertheless, hemophilic properties are also identified in induced antibody repertoire. The use of homophilicity of antibodies in the adaptive immunity signifies an archetypic antibody structure. The unique feature of homophilicity in the antibody repertoire also highlights an important mechanism to boost the antibody potency to protect against infection and atherosclerosis as well to treat cancer patients.
Document Type
Article
Publication Date
3-21-2016
Digital Object Identifier (DOI)
https://doi.org/10.3389/fimmu.2016.00106
Repository Citation
Kohler, Heinz; Bayry, Jagadeesh; and Kaveri, Srinivas V., "The Homophilic Domain – An Immunological Archetype" (2016). Microbiology, Immunology, and Molecular Genetics Faculty Publications. 88.
https://uknowledge.uky.edu/microbio_facpub/88
Notes/Citation Information
Published in Frontiers in Immunology, v. 7, article 106, p. 1-5.
Copyright: © 2016 Kohler, Bayry and Kaveri.
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