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Abstract
Phenotypic and functional properties of B lymphocytes from individual young and old mice of different inbred strains were studied. B lymphocyte subpopulation defined by the ratios of the densities of cell surface IgM and IgD were found to be altered with age. However, such alterations in B cell subsets were found only in 30-40% of the old mice. B cell mitogenic responses to anti-μ and anti-Lyb2 antibodies were decreased in a majority of DBA/2 mice. Proliferative responses to LPS and antiμ were reduced only in a minority of CBA/Ca mice but there was a very good correlation in the responsiveness of the old mice to LPS and anti-μ. The anomalous properties of the individual old mice of these inbred strains may be due to a heterogeneity in the effects of aging or due to environmental influences.
Document Type
Article
Publication Date
1990
Digital Object Identifier (DOI)
https://doi.org/10.1016/0047-6374(90)90073-O
Funding Information
This work was supported in part by the grants AI21490, AG05731 and the PSP funds of the University of Kentucky:
Repository Citation
Bondada, Subbarao; Morris, Joan; and Kryscio, Richard J., "Phenotypic and Functional Properties of B Lymphocytes from Aged Mice" (1990). Microbiology, Immunology, and Molecular Genetics Faculty Publications. 185.
https://uknowledge.uky.edu/microbio_facpub/185
Notes/Citation Information
© 1990 Elsevier Scientific Publishers lreland Ltd.