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Abstract
Chronic lymphocytic leukemia (CLL) patients progressively develop an immunosuppressive state. CLL patients have more plasma IL-10, an anti-inflammatory cytokine, than healthy controls. In vitro human CLL cells produce IL-10 in response to BCR cross-linking. We used the transgenic Eμ-T cell leukemia oncogene-1 (
Document Type
Article
Publication Date
6-15-2018
Repository Citation
Alhakeem, Sara S; McKenna, Mary K; Oben, Karine Z; Noothi, Sunil K; Rivas, Jacqueline R; Hildebrandt, Gerhard C; Fleischman, Roger A; Rangnekar, Vivek M; Muthusamy, Natarajan; and Bondada, Subbarao, "Chronic Lymphocytic Leukemia-Derived IL-10 Suppresses Antitumor Immunity." (2018). Microbiology, Immunology, and Molecular Genetics Faculty Publications. 157.
https://uknowledge.uky.edu/microbio_facpub/157
