Abstract
Listeria monocytogenes is one of several enteric microbes that is acquired orally, invades the gastric mucosa, and then disseminates to peripheral tissues to cause systemic disease in humans. Intravenous (i.v.) inoculation of mice with L. monocytogenes has been the most widely-used small animal model of listeriosis over the past few decades. The infection is highly reproducible and has been invaluable in deciphering mechanisms of adaptive immunity in vivo, particularly CD8+ T cell responses to intracellular pathogens. However, the i.v. model completely bypasses the gut phase of the infection. Recent advances in generating both humanized mice and murinized bacteria, as well as the development of a foodborne route of transmission has reignited interest in studying oral models of listeriosis. In this review, we analyze previously published reports to highlight both the similarities and differences in tissue colonization and host response to infection using either oral or i.v. inoculation.
Document Type
Review
Publication Date
3-2018
Digital Object Identifier (DOI)
https://doi.org/10.3390/pathogens7010013
Funding Information
S.E.F.D. was funded by the NIH (R01 AI101373; R21 AI30437).
Repository Citation
Pitts, Michelle G. and D'Orazio, Sarah E. F., "A Comparison of Oral and Intravenous Mouse Models of Listeriosis" (2018). Microbiology, Immunology, and Molecular Genetics Faculty Publications. 105.
https://uknowledge.uky.edu/microbio_facpub/105
Included in
Infectious Disease Commons, Medical Immunology Commons, Medical Microbiology Commons, Medical Pathology Commons, Molecular Genetics Commons, Pathogenic Microbiology Commons
Notes/Citation Information
Published in Pathogens, v. 7, issue 1, 13, p. 1-14.
© 2018 by the authors.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).