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Author ORCID Identifier

https://orcid.org/0009-0000-3912-990X

Date Available

5-1-2028

Year of Publication

2026

Document Type

Master's Thesis

Degree Name

Master of Science in Medical Sciences (MSMS)

College

Medicine

Department/School/Program

Medical Sciences

Faculty

Misung Jo

Faculty

Richard Grondin

Abstract

Successful ovulation and subsequent formation of the corpus luteum (CL) is essential for female fertility. These processes require tightly controlled changes in the expression of a myriad of genes. Transcription factors (TFs) induced in ovulatory follicles play critical roles in regulating the expression of these genes. Studies have shed light on FOS, a subunit of AP-1, as a critical TF involved in ovulation and luteal formation. The purpose of this study was first to determine the expression of Fos and Jun family members in response to ovulatory LH/hCG, then elucidate the roles of ovarian Fos and Junb expression during the ovulatory process. Herein, we show a rapid upregulation of Fos and Jun family members in response to hCG, with peak expression occurring at 3h and 11h after hCG stimulation. We also show conditional deletion of Fos or Junb in mice results in modest subfertility, while simultaneous deletion of Fos;Junb leads to an anovulation and infertility with reduced expression of key ovulatory genes, atypical steroidogenesis, and abnormal CL formation. These data indicate the loss of one subunit can be compensated by other family members, but the simultaneous loss of both FOS and JUNB is detrimental to gene regulation, ovulation, and fertility.

Digital Object Identifier (DOI)

https://doi.org/10.13023/etd.2026.380

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