Background: Obesity and type 2 diabetes mellitus (T2D) are known risk factors for colon cancer. Recent reports from a number of genome wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with obesity and T2D. Here we tested the hypothesis that these SNPs may also be associated with risk of colon cancer.
Methods: We genotyped nine SNPs reported in GWAS of obesity and/or T2D, including SNPs in HHEX, KCNJ11, SLC30A8, FTO, CDKN2, CDKAL1, TCF2, and the rs9300039 SNP in an intergenic region, in 561 colon cancer cases and 721 population controls.
Results: None of these SNPs were statistically significantly associated with colon cancer in our sample.
Conclusions: Overall, these results suggest that these obesity and T2D genetic susceptibility loci are unlikely to influence the risk of colon cancer.
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This research was supported by a Damon Runyon Cancer Research Foundation Clinical Investigator Award (CI-8), an R25 training grant from the National Cancer Institute (R25T CA094186), a K07 career development award from the National Cancer Institute (K07 CA136758-01A1), the Case Center for Transdisciplinary Research on Energetics and Cancer (1U54 CA-116867-01), and a National Cancer Institute K22 Award (1K22 CA120545-01).
Thompson, Cheryl L.; Plummer, Sarah J.; Tucker, Thomas C.; Casey, Graham; and Li, Li, "No Association of Obesity and Type 2 Diabetes Mellitus Related Genetic Variants With Colon Cancer" (2009). Markey Cancer Center Faculty Publications. 76.