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Abstract
Roughly one in ten children and young adults diagnosed with cancer has an underlying genetic variant that may explain his/her malignancy. It is critical to identify patients with cancer predisposition syndromes (CPSs) to provide personalized cancer treatment, surveillance, counseling, psychosocial support, and in some cases, risk-reducing interventions to maximize long-term outcomes. Over the past five years, we developed a comprehensive pediatric CPS program at our institution. We engaged our institutional adult cancer center for clinical cancer genetic counseling services and needed research shared resource facilities. We also initiated a clinical study called “Project Inherited Cancer Risk” (PICR) to identify pediatric oncology patients affected by CPSs through universal germline NextGen sequencing of a known panel of CPS genes. Finally, we have engaged the CPS community to learn how we can better serve them. Here, we describe the rationale, process, challenges and opportunities of developing a multidisciplinary CPS clinical service in a medium-sized academic pediatric oncology center.
Document Type
Article
Publication Date
2026
Digital Object Identifier (DOI)
https://doi.org/10.3389/fonc.2026.1794874
Funding Information
The author(s) declared that financial support was received for this work and/or its publication. We acknowledge the Markey Cancer Center’s CCSG grant (NIH P30 CA177558s) for its support of several shared resource core facilities necessary critical to our efforts in pediatric cancer predisposition.
Repository Citation
Harrington, Amanda M. and D'Orazio, John August, "Developing a multidisciplinary pediatric cancer predisposition service at a mid-sized children’s hospital" (2026). Markey Cancer Center Faculty Publications. 502.
https://uknowledge.uky.edu/markey_facpub/502
Notes/Citation Information
© 2026 Harrington and D’Orazio. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.